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GenomicsRetrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro B cells
The establishment of distinct transcription programs during development is controlled by transcription factor networks acting in specific chromatin environments. The H3K9me3-specific histone methyltransferase Setdb1 impacts on transcriptional regulation by repressing both developmental genes and ret...
ORGANISM(S): Mus musculus 
2016-07-20 | E-GEOD-77636 | biostudies-arrayexpress
ProteomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1 mediated H3K9me3 and DNA methylation. However, the protein network which r...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027368 | Pride
Morc3 Endogenous retroviruses Erv Histone h3.3 Daxx Setdb1 
TranscriptomicsSuv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted embryonic cells into differentiated somatic c...
ORGANISM(S): Xenopus laevis 
2013-02-06 | E-GEOD-41256 | biostudies-arrayexpress
TranscriptomicsChIP-seq data from DG75 cells with the BZLF1 specific antibody BZ1
ChIP-seq experiments with the antibody BZ1 directed against the EBV protein BZLF1 prior to and 15 hours post induction with doxycycline (100 ng/ml). The doxycycline regulated conditional BZLF1 allele is encoded by an inducible oriP plasmid vector stably introduced into DG75 cells. Experiments were p...
ORGANISM(S): Homo sapiens 
2021-02-07 | E-MTAB-8422 | biostudies-arrayexpress
TranscriptomicsCapture-C identification of chromatin interactions of 53 selected cellular loci prior to and post induction of EBV's lytic cycle in Raji cells
Identification of specific chromatin interactions of 53 selected genes with the Capture-C technique in Raji iBZLF1 cells prior to and 6 or 15 h after induction of EBV’s lytic cycle. The experiments were performed as triplicates.
ORGANISM(S): Homo sapiens 
2019-04-05 | E-MTAB-7825 | biostudies-arrayexpress
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