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TranscriptomicsTranscription profiling of mouse embryonic stem (ES) cells overexpressing serum response factor SRF to identify potential transcriptional targets of SRF
Empty vector, SRF-dM-VP16 (control construct lacking the SRF DNA binding domain), or SRF-VP16 were expressed in wild-type ES cells (E14wt), SRF heterozygotes (E99-/+) or two SRF ko cell lines (E81-/-,E100-/-). RNA was harvested 72h after transfection. Each condition was performed in duplicate, excep...
ORGANISM(S): Mus musculus 
2007-11-06 | E-GEOD-1948 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem (ES) cells following stimulation with fetal bovine serum at various time points up to 180 minutes to identify potential targets of SRF
Murine ES cells of different Srf genotype (E14wt, E100-/-, E100-/- rescue (Srf transgene)) were stimulated with FBS for 0-180 min. RNA was harvested and hybridized to Affymetrix MGU74A arrays.
ORGANISM(S): Mus musculus 
2007-11-02 | E-GEOD-1949 | biostudies-arrayexpress
Proteomicsprotein turnover during homeostatic plasticity
Using quantitative proteomics we identified group of synaptic genes with decreased protein synthesis during homeostatic plasticity. To obtain further information about their mRNA levels/sequences (3’UTR) we performed polyA RNAseq. Using EISA analysis of Ribominus RNAseq dataset we could further diff...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-04-05 | PXD004150 | Pride
Neuron silac homeostatic plasticity 
Proteomicscompartmentalized protein expression in rat hippocampal neurons undergoing homeostatic plasticity
Synaptic scaling is a form of homeostatic plasticity which allows neurons to adjust their action potential firing rate in response to chronic alterations in neural activity. Synaptic scaling requires profound changes in gene expression, but the relative contribution of local and cell-wide mechanisms...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-09 | PXD020745 | Pride
Neurons Stimulation Homeostatic plasticity Hippocampus Rat Cellculture Ptx Dendrites 
ProteomicsA human-specific microRNA controls the timing of excitatory synaptogenesis
The development of neural circuits in the human cortex is considerably prolonged in comparison to non-human primates, a trait which contributes to the remarkable cognitive capacity of modern humans. In contrast to protein-coding genes, non-coding genes underwent a dramatic expansion during evolution...
ORGANISM(S): Homo sapiens (Human) 
2025-11-03 | PXD045809 | Pride
Neuron Development Human Ipsc 
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