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TranscriptomicsChromatin immunoprecipitation of human HNF3b and E2F4, and mouse NeuroD1, for THEME analysis
Genome-wide chromatin-immunoprecipitation (ChIP-chip) detects binding of transcriptional regulators to DNA in vivo at low resolution. Motif discovery algorithms can be used to discover sequence patterns in the bound regions that may be recognized by the immunoprecipitated protein. However, the disco...
ORGANISM(S): Mus musculus 
2006-05-09 | E-WMIT-8 | biostudies-arrayexpress
ProteomicsSelective inhibitors of SARM1 targeting an allosteric cysteine in the autoregulatory ARM domain
The NAD hydrolase (NADase) SARM1 acts as a central executioner of programmed axon death and is a possible therapeutic target for neurodegenerative disorders. While orthosteric inhibitors of SARM1 have been described, this multi-domain enzyme is also subject to intricate forms of autoregulation, sugg...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD035400 | Pride
Covalent Chemical proteomics Allosteric inhibition Axonopathy Neurodegeneration 
UnknownCommunity consultation for exception from informed consent studies: are market research surveys representative of the target community populations?
Not available
S-EPMC12706250 | biostudies-literature
GenomicsAlzheimer's Disease Sequencing Project (ADSP)

The overarching goals of the ADSP are to: (1) identify new genomic variants contributing to increased risk of developing AD, (2) identify new genomic variants contributing to protection against developing AD, and (3) provide insight as to why individuals with known risk factor variants escape fro...

phs000572.v1.p1 | EGA
TranscriptomicsNiche-based screening identifies small-molecule inhibitors of leukemia stem cells
Efforts to develop more effective therapies for acute leukemia may benefit from high-throughput screening systems that reflect the complex physiology of the disease, including leukemia stem cells (LSCs) and supportive interactions with the bone-marrow microenvironment. The therapeutic targeting of L...
ORGANISM(S): Mus musculus 
2013-09-20 | E-GEOD-51033 | biostudies-arrayexpress
UnknownCerebral Palsy and Motor Impairment After Extreme Prematurity: Prediction of Diagnoses at Ages 2 and 10 Years.
Not available
S-EPMC11239312 | biostudies-literature
UnknownNeonatal inflammation and its association with asthma and obesity in late childhood among individuals born extremely preterm.
Not available
S-EPMC12435514 | biostudies-literature
UnknownEvaluating drug targets through human loss-of-function genetic variation.
Not available
S-EPMC7272226 | biostudies-literature
UnknownMining the human phenome using allelic scores that index biological intermediates.
Not available
S-EPMC3814299 | biostudies-literature
UnknownLong-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen receptor-positive breast cancer: ATLAS, a randomised trial.
Not available
S-EPMC3596060 | biostudies-literature
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