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ProteomicsTargeting the paralog encoded protein for degradation accounts for the opposite roles of NRBP1 and NRBP2 in regulating LINE1 retrotransposition
The activation of Long Interspersed Nuclear Element 1 (LINE1/L1) retrotransposons not only leads to genome instability, a factor associated with the development of human diseases, but also plays crucial biological roles in fostering genetic diversity and neuronal functions. Therefore, investigating ...
ORGANISM(S): Homo sapiens (Human) 
2025-06-07 | PXD051452 | Pride
Line1 Retrotransposon Nrbp2 Nrbp1 
UnknownAn IL-4 signalling axis in bone marrow drives pro-tumorigenic myelopoiesis.
Not available
S-EPMC11189607 | biostudies-literature
UnknownMonocytes re-enter the bone marrow during fasting and alter the host response to infection.
Not available
S-EPMC10101885 | biostudies-literature
UnknownNKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer.
Not available
S-EPMC9479122 | biostudies-literature
UnknownDendritic cells type 1 control the formation, maintenance, and function of tertiary lymphoid structures in cancer.
Not available
S-EPMC11703156 | biostudies-literature
UnknownInterleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis.
Not available
S-EPMC10524830 | biostudies-literature
UnknownHLA-E and NKG2A Mediate Resistance to <i>M. bovis</i> BCG Immunotherapy in Non-Muscle-Invasive Bladder Cancer.
Not available
S-EPMC11398371 | biostudies-literature
Genomicsena-DATASET-UCAM-GEL-15-04-2015-15:15:23:555-345 - samples
Whole exome sequencing BAM files for samples from the BRIDGE Consortium with pathogenic or likely pathogenic variants on genes linked to bleeding or platelet disorders.
EGAD00001001333 | EGA
GenomicsSequencing of heritable Bleeding and Platelet Disorders
The BRIDGE-BPD study aims to discover new causal genes for Bleeding and Platelet Disorders (BPD) by high throughput sequencing using cluster analyses based on improved and standardized deep phenotyping of cases. BPD is one of the 13 Rare Disease projects under the NIHR BioResource Rare Diseases BRID...
EGAS00001001172 | EGA
GenomicsNIHR BioResource DAC
Data Access Committee EGAC00001000259
EGAC00001000259 | EGA
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