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UnknownInhibition of ADAM17 impairs endothelial cell necroptosis and blocks metastasis.
Not available
S-EPMC8689681 | biostudies-literature
UnknownHypophosphatemic rickets with hypercalciuria due to mutation in SLC34A3/NaPi-IIc can be masked by vitamin D deficiency and can be associated with renal calcifications.
Not available
S-EPMC4777409 | biostudies-literature
TranscriptomicsDual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer
Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and t...
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-43610 | biostudies-arrayexpress
ProteomicsCell-autonomous hepatocyte-specific GP130 signalling alone is sufficient to trigger robust innate immune response in mice
Members of the IL-6 cytokine family contribute to inflammatory and regenerative processes. Engagement of the signalling receptor subunit gp130 is common to almost all members of the family. In the liver, all major cell types respond to IL-6, making it difficult to delineate cell type-specific effect...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-20 | PXD020744 | Pride
Innate immunity Acute-phase response Il-6 Gp130 
UnknownDistinct sets of tethering complexes, SNARE complexes, and Rab GTPases mediate membrane fusion at the vacuole in Arabidopsis.
Not available
S-EPMC5877921 | biostudies-literature
ProteomicsHuman Bile LC-MS/MS
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000082926 | MassIVE
UnknownADAM17 is required for EGF-R-induced intestinal tumors via IL-6 trans-signaling.
Not available
S-EPMC5881468 | biostudies-literature
ProteomicsUBQLN4 regulates double-strand break repair by repressing homologous recombination and is overexpressed in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis and its major role in genome stability and maintenance is rapidly emerging. Here, we identify the proteasomal shuttle factor ubiquilin-4 (UBQLN4) as a major component of the DNA damage response. We found a homozygous ...
ORGANISM(S): Homo sapiens (Human) 
2019-02-12 | PXD011488 | Pride
Cancer Phosphorylation Dna-damage 
UnknownAn archaeal lid-containing feruloyl esterase degrades polyethylene terephthalate.
Not available
S-EPMC10495362 | biostudies-literature
MetabolomicsPlant species richness elicits changes in the metabolome of grassland species via soil biotic legacy
Species-rich plant communities can induce unique soil biotic legacy effects through changing the abundance and composition of soil biota. These soil legacy effects can cause feedbacks to influence plant performance. In addition, soil biota can induce (defensive) secondary metabolites in shoots ...
2019-05-30 | MTBLS544 | MetaboLights
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