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UnknownCorrelates of evolutionary rates in the murine sperm proteome.

Background

Protein-coding genes expressed in sperm evolve at different rates. To gain deeper insight into the factors underlying this heterogeneity we examined the relative importance of a diverse set of previously described rate correlates in determining the evolution of murine sperm protei...
S-EPMC5870804 | biostudies-literature
ModelsKrohn2011 - Cerebral amyloid-β proteostasis regulated by membrane transport protein ABCC1
Krohn2011 - Cerebral amyloid-β proteostasis regulated by membrane transport protein ABCC1 This model is described in the article: Cerebral amyloid-β proteostasis is regulated by the membrane transport protein ABCC1 in mice. Krohn M, Lange C, Hofrichter J, Scheffler K, Stenze...
2024-09-02 | BIOMD0000000618 | BioModels
UnknownEffects of different kinds of essentiality on sequence evolution of human testis proteins.
We asked if essentiality for either fertility or viability differentially affects sequence evolution of human testis proteins. Based on murine knockout data, we classified a set of 965 proteins expressed in human seminiferous tubules into three categories: proteins essential for prepubertal survival...
S-EPMC5341092 | biostudies-literature
UnknownTemperature-responsive miRNAs in Drosophila orchestrate adaptation to different ambient temperatures.
The majority of Drosophila genes are expressed in a temperature-dependent manner, but the way in which small RNAs may contribute to this effect is completely unknown as we currently lack an idea of how small RNA transcriptomes change as a function of temperature. Applying high-throughput sequ...
S-EPMC5558905 | biostudies-literature
UnknownEnhanced stability of a chimeric hepatitis B core antigen virus-like-particle (HBcAg-VLP) by a C-terminal linker-hexahistidine-peptide.

Background

Virus-like-particles (VLPs) are attractive nanoparticulate scaffolds for broad applications in material/biological sciences and medicine. Prior their functionalization, specific adaptations have to be carried out. These adjustments frequently lead to disordered particles, but the ...
S-EPMC5897928 | biostudies-literature
Unknown3D Melanoma Cocultures as Improved Models for Nanoparticle-Mediated Delivery of RNA to Tumors.
Cancer therapy is an emergent application for mRNA therapeutics. While in tumor immunotherapy, mRNA encoding for tumor-associated antigens is delivered to antigen-presenting cells in spleen and lymph nodes, other therapeutic options benefit from immediate delivery of mRNA nanomedicines directly to t...
S-EPMC8946997 | biostudies-literature
UnknownQuantitative size-resolved characterization of mRNA nanoparticles by in-line coupling of asymmetrical-flow field-flow fractionation with small angle X-ray scattering.
We present a generically applicable approach to determine an extensive set of size-dependent critical quality attributes inside nanoparticulate pharmaceutical products. By coupling asymmetrical-flow field-flow fractionation (AF4) measurements directly in-line with solution small angle X-ray scatteri...
S-EPMC10516866 | biostudies-literature
ProteomicsTowards a better understanding the testicular proteome of domestic pig
For gaining additional insights into the composition of the testicular proteome of the domestic pig (Sus scrofa domestica), we conducted 2DE-MS. Two-dimensional SDS PAGE was run on testicular lysates of three boars, with three gels per boar. Upon matching across gels, we arbitrarily selected protein...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2022-08-12 | PXD015649 | Pride
Proteomics Sus srofa 2de-ms 
UnknownThe transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.
Robust cytotoxic CD8(+) T-cell response is important for immunity to intracellular pathogens. Here, we show that the transcription factor IFN Regulatory Factor 4 (IRF4) is crucial for the protective CD8(+) T-cell response to the intracellular bacterium Listeria monocytogenes. IRF4-deficient (Irf4(-/...
S-EPMC3773801 | biostudies-literature
TranscriptomicsCystic leukoencephalopathy without megalencephaly
The cystic leukoencephalopathy without megalencephaly has been defined as distinct autosomal-recessive syndrome of quasi-static encephalopathy with normo- or microcephaly, impaired psychomotor development and characteristic pattern on brain MRI. We identified mutations in the gene encoding the RNASE...
ORGANISM(S): Homo sapiens 
2009-06-02 | E-GEOD-11964 | biostudies-arrayexpress
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