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TranscriptomicsThe glucosinolate metabolite 1-methoxy-3-indolylmethyl alcohol induces a gene expression profile in mouse liver similar to the expression signature caused by known genotoxic hepatocarcinogens
Breakdown products of some glucosinolates M-bM-^@M-^S defense chemicals of Brassicales M-bM-^@M-^S induce detoxifying enzymes and demonstrate preventive activities against chemically induced tumorigenesis in animal models. However, other breakdown products are genotoxic. 1-Methoxy-3-indolylmethyl al...
ORGANISM(S): Mus musculus 
2015-02-18 | E-GEOD-61494 | biostudies-arrayexpress
UnknownBaseline α-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort.
Not available
S-EPMC12354789 | biostudies-literature
TranscriptomicsMolecular Classification and Prediction of Survival in Non-Small-Cell Lung Cancer
BACKGROUND: Global gene expression analysis provides a comprehensive molecular characterization of non-small cell lung cancer. The aim of this study was to evaluate the feasibility of integrating expression profiling into routine clinical work-up by including minute bronchoscopic biopsies and develo...
ORGANISM(S): Homo sapiens 
2008-04-10 | E-GEOD-11117 | biostudies-arrayexpress
TranscriptomicsDAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage [N2, daf-2, daf-16, daf-2;daf-16]
Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature aging. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates wi...
ORGANISM(S): Caenorhabditis elegans 
2014-11-18 | E-GEOD-51162 | biostudies-arrayexpress
UnknownGlutamine promotes human CD8+ T cells and counteracts imiquimod-induced T cell hyporesponsiveness.
Not available
S-EPMC11088342 | biostudies-literature
UnknownChallenges in the development of an immunochromatographic interferon-gamma test for diagnosis of pleural tuberculosis.
Not available
S-EPMC3871622 | biostudies-literature
ProteomicsSystematic identification of factors involved in the silencing of germline genes in mouse embryonic stem cells
In mammals, many germline genes are repressed by epigenetic mechanisms to prevent their illegitimate expression in embryonic and somatic cells. To advance our understanding of the complete mechanisms restricting the expression of germline genes in mammals, we analyzed the chromatin signature of germ...
ORGANISM(S): Mus musculus (Mouse) 
2023-02-03 | PXD030666 | Pride
Germline genes Erh Prc1.6 Shfm1 Crispr-cas9 screen Dna methylation Es cells Usp7 
UnknownGenetic analysis and natural history of Parkinson's disease due to the LRRK2 G2019S variant.
Not available
S-EPMC11146432 | biostudies-literature
UnknownFunctional recovery following hospitalisation of patients diagnosed with COVID-19: a protocol for a longitudinal cohort study.
Not available
S-EPMC8671848 | biostudies-literature
UnknownUnderrepresented Populations in Parkinson's Genetics Research: Current Landscape and Future Directions.
Not available
S-EPMC10360137 | biostudies-literature
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