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TranscriptomicsTranscriptional profiling predicts overwhelming homology of Schwann cells, olfactory ensheating cells and Schwann cell-like glia
The objective of this study was to compare the transcriptomes of uninfected and canine distemper virus-infected Schwann cells, olfactory ensheating cells, central nervous system Schwann cell-like glia, and fibroblasts cultured under identical conditions in vitro.
ORGANISM(S): Canis familiaris 
2014-06-02 | E-MTAB-2061 | biostudies-arrayexpress
TranscriptomicsOverexpression of c-Jun in mouse Schwann cells of uninjured nerves
Two mouse lines, OE/+ and OE/OE were generated expressing graded elevation (6 fold and 28 fold, respectively) of c-Jun protein selectively in Schwann cells. The effects of this on global gene expression and cellular structure in uninjured nerves was analysed during development and in the adult. Chan...
ORGANISM(S): Mus musculus 
2017-10-16 | E-MTAB-6138 | biostudies-arrayexpress
TranscriptomicsAblation of Dicer from murine Schwann cells increases their proliferation while blocking myelination
The myelin sheaths that surround the thick axons of the peripheral nervous system are produced by the highly specialized Schwann cells. Differentiation of Schwann cells and myelination occur in discrete steps. Each of these requires coordinated expression of specific proteins in a precise sequence, ...
ORGANISM(S): Mus musculus 
2010-12-01 | E-GEOD-22023 | biostudies-arrayexpress
TranscriptomicsFunctions of HDAC1 and HDAC2 in Schwann cells during postnatal
The aim of our study is to determine the functions of histone deacetylases (HDACs) 1 and 2 in Schwann cells during postnatal development of the peripheral nervous system (PNS). Schwann cells are the myelinating glial cells of the PNS. At birth, mouse sciatic nerves mature in 2 subsequent phases: 1/ ...
ORGANISM(S): Mus musculus 
2011-02-25 | E-GEOD-27451 | biostudies-arrayexpress
TranscriptomicsDirect genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (human)
Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mese...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57518 | biostudies-arrayexpress
TranscriptomicsHuman Schwann cells generated from human epidermal neural crest stem cells (hEPI-NCSC)
The goal was to determine differentially expressed genes between hEPI-NCSC and Schwann cells generated thereof. RNA was isolated from (a) ex vivo expanded hEPI-NCSC (XP; Clewes O et al, 2011) and from (b) human Schwann cells that were differentiated from hEPI-NCSC (unpublished data) Three samples of...
ORGANISM(S): Homo sapiens 
2014-12-15 | E-GEOD-61273 | biostudies-arrayexpress
TranscriptomicsGenome-wide expression analysis of Schwann cells upon Wnt loss-of-function and gain-of-function treatments
Analysis of genes regulated by canonical Wnt signaling in the murine primary Schwann cells. Total RNA from b-catenin fl/fl Schwann cells, after introducing loss-of-function mutations with HTN-cre, or mimicking gain-of-function mutations with Chir98014 or Wnt3a-treatments, was compared to the respect...
ORGANISM(S): mus musculus 
2013-10-25 | E-MTAB-1943 | biostudies-arrayexpress
GenomicsDNA methylation status of myelinating Schwann cells during development and in diabetic neuropathy [Bisulfite-Seq2]
DNA methylation is a key epigenetic regulator of mammalian embryogenesis and somatic cell differentiation. Using high-resolution genome-scale maps of methylation patterns, we show that the formation of myelin in the peripheral nervous system, proceeds with progressive DNA demethylation, which coinci...
ORGANISM(S): Mus musculus 
2014-01-27 | E-GEOD-51031 | biostudies-arrayexpress
TranscriptomicsDirect genesis of functional rodent and human Schwann cells from skin mesenchymal precursors (rat)
Recent reports of directed reprogramming have raised questions about the stability of cell lineages. Here, we have addressed this issue, focusing upon skin-derived precursors (SKPs), a dermally-derived precursor cell. We show by lineage tracing that murine SKPs from dorsal skin originate from mese...
ORGANISM(S): Rattus norvegicus 
2014-08-01 | E-GEOD-57505 | biostudies-arrayexpress
TranscriptomicsEffect of live Mycobacterium leprae on primary human Schwann cell gene expression
In attempt to understand M.leprae interaction with the human host, Applied Biosystems microarrays containing 30,865 probles were used to identify modulated genes in primary human Schwann Cells (SC) infected with live M. leprae at two early time points, 24 and 48 hours. A total of 4 independent exper...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-35423 | biostudies-arrayexpress
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