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ProteomicsScube2 primes Dispatched and ADAM10-mediated Shh release by recruiting HDL acceptors to the plasma membrane
Sonic hedgehog (Shh) morphogens are lipidated proteins that firmly attach to the outer plasma membrane (PM) of the cells that produce them. The process by which Shh is solubilized includes the transmembrane protein Dispatched1 (Disp), the soluble glycoprotein Scube2, the proteolytic removal of lipid...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD071371 | Pride
A disintegrin and metalloproteinase 10 Cholesterol Heparan sulfate Scube2 Dispatched Hedgehog High-density lipoprotein 
GenomicsSCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches
SCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches
PRJNA773046 | ENA
TranscriptomicsSCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches
Estrogen receptor (ER)-positive luminal breast cancer is a subtype with generally lower risk of metastasis to most distant organs. However, bone recurrence occurs preferentially in luminal cancer. The mechanisms of the subtype-specific organotropism remain elusive. Here we show that an ER-regulated ...
ORGANISM(S): Mus musculus 
2023-04-15 | GSE186230 | GEO
UnknownSCUBE2 mediates bone metastasis of luminal breast cancer by modulating immune-suppressive osteoblastic niches.
Not available
S-EPMC10235122 | biostudies-literature
UnknownCircular RNA circ_SETD2 represses breast cancer progression via modulating the miR-155-5p/SCUBE2 axis.
Not available
S-EPMC7712504 | biostudies-literature
UnknownDomain and functional analysis of a novel breast tumor suppressor protein, SCUBE2.
Not available
S-EPMC3143662 | biostudies-literature
UnknownThe Inhibitory Effect of (-)-Epigallocatechin-3-Gallate on Breast Cancer Progression via Reducing SCUBE2 Methylation and DNMT Activity.
Not available
S-EPMC6719997 | biostudies-literature
UnknownBridging the gap: heparan sulfate and Scube2 assemble Sonic hedgehog release complexes at the surface of producing cells.
Not available
S-EPMC4873810 | biostudies-literature
UnknownSCUBE2 as a Marker of Resistance to Taxane-based Neoadjuvant Chemotherapy and a Potential Therapeutic Target in Breast Cancer.
Not available
S-EPMC9806940 | biostudies-literature
GenomicsRUNX2 promotes pulmonary fibrosis through the conversion of alveolar fibroblasts into pathological fibroblasts
A hallmark of pulmonary fibrosis is aberrant activation of lung fibroblasts into pathological fibroblasts producing excessive extracellular matrix (ECM). Thus, identification of key regulator(s) driving the generation of pathological fibroblasts can inform effective countermeasures against disease p...
ORGANISM(S): Mus musculus 
2024-11-25 | GSE278419 | GEO
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