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ProteomicsSDC4 drives fibrotic remodeling of the intervertebral disc under altered spinal loading
In this study, we study protein expression profiles in Sdc4-deleted NP cells under mechanical loading and natural physiological loading.
ORGANISM(S): Mus musculus (Mouse) 
2025-10-13 | PXD061689 | Pride
Syndecan 4 Nucleus pulposus Proteomic Sdc4 Intervertebral disc 
Genomicshighly throughout RNA sequncing analysis of WT and SDC4-KD endothelium stimulated by TNF-a
highly throughout RNA sequncing analysis of WT and SDC4-KD endothelium stimulated by TNF-a
PRJNA1524250 | ENA
GenomicsSdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine
Sdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine
PRJNA1018948 | ENA
UnknownTherapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma.
Not available
S-EPMC8121893 | biostudies-literature
UnknownFibrotic lung ECM upregulates SDC4/integrin-αvβ1 interaction and the interfering peptide SDC4<sub>87-131</sub> and its derivative peptides alleviate pulmonary fibrosis.
Not available
S-EPMC12313019 | biostudies-literature
TranscriptomicsSdc4 deletion perturbs intervertebral disc matrix homeostasis and promotes early osteopenia in the aging mouse spine
Transcriptional analysis of 6-month-old primary nucleus pulposus (NP) mouse disc tissues from wild-type (WT) and SDC4 KO mice, which harbor deletions of exon 2 to part of exon 5 that endcodes the N-terminal coding region. Breeder mice were provided by Dr. Michael Simons. SDC4's regulation of cytokin...
ORGANISM(S): Mus musculus 
2024-09-01 | GSE243573 | GEO
Transcriptomicshighly throughout RNA sequncing analysis of WT and SDC4-KD endothelium stimulated by TNF-a
To identify downstream molecules and signaling pathways regulated by SDC4 during endothelial inflammatory activation, RNA sequencing (RNA-seq) was performed following SDC4 knockdown in TNF-α-stimulated endothelial cells. In this project, differentially expressed genes were identified using a thresho...
ORGANISM(S): Homo sapiens 
2026-09-10 | GSE346259 | GEO
UnknownEltrombopag binds SDC4 directly and enhances MAPK signaling and macropinocytosis in cancer cells.
Not available
S-EPMC9251693 | biostudies-literature
GenomicsEndothelial Kallikrein-Related Peptidase 8 Promotes Diabetic Nephropathy via Reducing SDC4 Expression and Enhancing LIF Release
Endothelial Kallikrein-Related Peptidase 8 Promotes Diabetic Nephropathy via Reducing SDC4 Expression and Enhancing LIF Release
PRJNA1073260 | ENA
ProteomicsSyndecan-4 is a maestro of gastric cancer cell invasion and communication that underscores poor survival
Gastric cancer is a dominating cause of cancer-associated mortality with limited therapeutic options. Here, we show that syndecan-4 (SDC4), a plasma membrane proteoglycan, is highly expressed in intestinal subtype gastric tumours and that this signature associates with patients’ poor survival. Furth...
ORGANISM(S): Homo sapiens (Human) 
2023-05-05 | PXD035679 | Pride
Extracellular vesicles Extracellular communication Gastric cancer Syndecan-4 Heparan sulfate proteoglycans Cancer cell invasion 
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