Sealing zone - OmicsDI

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Lab affiliation

Institut für Pathologie Uniklinik Köln, Kerpener Straße 62, 50937 Köln (1)
University of Lausanne, Faculty of Biology and Medicine, Department of Plant Molecular Biology, 1015 Lausanne, Switzerland (1)
Women’s Health Integrated Research Center Inova Women’s Service Line Inova Health System 3289 Woodburn Rd, Annandale, VA 22042, USA (1)
Institute of Experimental Hematology, School of Medicine, Technische Universität München, Munich, D-81675, Germany; Max-Planck Institute of Biochemistry, D-82152 Martinsried (1)
Centre de Recherche en Biologie cellulaire de Montpellier (CRBM), CNRS UMR 5237, Montpellier University, France (1)

Tags

xref:PubMed:34404802 (1)
xref:PubMed:32265273 (1)

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Low kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones

Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist mainly of densely packed podosomes tightly inter-connected by actin fibers. Their formation requires the presence of the hematopoietic integrin reg...

ORGANISM(S): Mus musculus (Mouse)

2021-11-25 | PXD026711 | Pride