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ProteomicsLow kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist mainly of densely packed podosomes tightly inter-connected by actin fibers. Their formation requires the presence of the hematopoietic integrin reg...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD026711 | Pride
Sealing zone Podosome Osteoclast Bone resorption Kindlin-3 Integrin 
ProteomicsStructural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state
Kindlin-1, -2, and -3, directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their functional significance and link to several diseases, structural information on full-length kindlin proteins remains unknown. Here, we report the crystal structure of human...
ORGANISM(S): Homo sapiens (Human) 
2020-06-08 | PXD019110 | Pride
Kindlin  ferm  fermitin  kindlin-3  integrin  extracellular matrix  dsso 
GenomicsExpression Data from murine follicular B cells with or without Kindlin-3 knockout
Expression Data from murine follicular B cells with or without Kindlin-3 knockout
PRJNA721965 | ENA
TranscriptomicsExpression Data from murine follicular B cells with or without Kindlin-3 knockout
Integrin-mediated interactions between hematopoietic cells and their microenvironment are important for the development and function of immune cells. Here, we studied the role of the integrin adaptor Kindlin-3 in B cell homeostasis. To this end, we compared B cell development in B cell specific knoc...
ORGANISM(S): Mus musculus 
2026-03-23 | GSE172080 | GEO
GenomicsCRISPR/Cas9-mediated loss of FERMT3 reveals kindlin-3 independent neutrophil activity in Leukocyte Adhesion Deficiency III.
CRISPR/Cas9-mediated loss of FERMT3 reveals kindlin-3 independent neutrophil activity in Leukocyte Adhesion Deficiency III.
PRJNA1454520 | ENA
TranscriptomicsCRISPR/Cas9-mediated loss of FERMT3 reveals kindlin-3 independent neutrophil activity in Leukocyte Adhesion Deficiency III.
Mutations in human FERMT3, which encodes for the kindlin-3 protein, impair integrin activity and function in neutrophils from patients with leukocyte adhesion deficiency III (LAD-III). These patients have severe and recurrent life-threatening bacterial and fungal infections early in life. Although t...
ORGANISM(S): Homo sapiens 
2026-10-02 | GSE328304 | GEO
UnknownDifferences in self-association between kindlin-2 and kindlin-3 are associated with differential integrin binding.
Not available
S-EPMC7415974 | biostudies-literature
UnknownKindlin-3 mutation in mesenchymal stem cells results in enhanced chondrogenesis.
Not available
S-EPMC7874523 | biostudies-literature
UnknownExpression of kindlin-3 in melanoma cells impedes cell migration and metastasis.
Not available
S-EPMC5810813 | biostudies-literature
UnknownA novel tumor suppressor function of Kindlin-3 in solid cancer.
Not available
S-EPMC4253411 | biostudies-literature
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