Sort   by:  
 Page size 
TranscriptomicsExpression data of cDNA from the ACHN control and Kindlin-2-depleting cells
Kindlin-2, an integrin-interacting FERM-domain-containing protein, has been known to play critical roles for tumor progression. However, the role of Kindlin-2 in renal cell carcinoma (RCC) progression has not been reported. We aim to investigate the role of Kindlin-2 in the progression of RCC and th...
ORGANISM(S): Homo sapiens 
2015-12-16 | E-GEOD-76020 | biostudies-arrayexpress
ProteomicsLow kindlin-3 levels in osteoclasts of kindlin-3 hypomorphic mice result in osteopetrosis due to leaky sealing zones
Osteoclasts form special integrin-mediated adhesion structures called sealing zones that enable them to adhere to and resorb bone. Sealing zones consist mainly of densely packed podosomes tightly inter-connected by actin fibers. Their formation requires the presence of the hematopoietic integrin reg...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-25 | PXD026711 | Pride
Sealing zone Podosome Osteoclast Bone resorption Kindlin-3 Integrin 
ProteomicsMass spectrometry proteomics detecting interaction proteins of Kindlin-2
We aim to find out the Kindlin-2 interaction proteins. We transfected plasmids Flag or Flag-Kindlin-2 to HKC cell lines and then used Flag-M2 beads to do the coimmunoprecipitation experiments and followed by NuPAGE Tris-Acetate Mini Gels detection and stained by Coomassie brilliant blue. Compared th...
ORGANISM(S): Homo sapiens (Human) 
2019-12-16 | PXD016008 | Pride
Human renal tubular epithelial cell(hkc) 
ProteomicsStructural basis of human full-length kindlin-3 homotrimer in an auto-inhibited state
Kindlin-1, -2, and -3, directly bind integrin β cytoplasmic tails to regulate integrin activation and signaling. Despite their functional significance and link to several diseases, structural information on full-length kindlin proteins remains unknown. Here, we report the crystal structure of human...
ORGANISM(S): Homo sapiens (Human) 
2020-06-08 | PXD019110 | Pride
Kindlin  ferm  fermitin  kindlin-3  integrin  extracellular matrix  dsso 
ProteomicsMass spectrometry-based analysis of kindlin phosphorylation, ubiquitination and interactome
Kindlin is an essential activator of integrins and thus indispensable in cell to extracellular matrix (ECM) adhesion. Kindlin abundance and functions are tightly regulated by multiple mechanisms including post-translational modifications (PTMs). Despite the critical roles of kindlin during embryonic...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-02-22 | PXD031829 | Pride
Kindlin Ubiquitination Phosphorylation Mass spectrometry 
GenomicsKindlin-2 Orchestrates brown adipose tissue maintenance and thermogenic programing
Kindlin-2 Orchestrates brown adipose tissue maintenance and thermogenic programing
PRJNA1309102 | ENA
GenomicsRole of Kindlin-2 in breast cancer immune evasion
Role of Kindlin-2 in breast cancer immune evasion
PRJNA1219181 | ENA
ProteomicsMarch5-mediated Trim28 degradation preserves islet β-cell function in mice
Insulin deficiency from β-cell dysfunction underpins both type 1 and type 2 diabetes. However, the regulatory pathways underlying β-cell function remain incompletely understood. Here, we identify that March5 and Trim28 as key modulators of β-cell function. March5 is downregulated and Trim28 upregula...
ORGANISM(S): Homo sapiens (Human) 
2025-07-24 | PXD066332 | Pride
Islet transplantation Mafa Kindlin-2 Insulin secretion Glucose intolerance 
GenomicsATAC-seq analysis of Kindlin-2 and Rela K.O. mouse fibroblasts
ATAC-seq analysis of Kindlin-2 and Rela K.O. mouse fibroblasts
PRJNA418961 | ENA
GenomicsLoss of Kindlin-1 drives a more aggressive phenotype in cutaneous squamous cell carcinoma
Loss of Kindlin-1 drives a more aggressive phenotype in cutaneous squamous cell carcinoma
PRJNA992569 | ENA
Sort   by:  
 Page size