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ProteomicsHDX of SEB and Neutralizing mAbs
Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-27 | PXD051141 | Pride
Hdx-ms Hydorgen deuterium exchange Seb 
TranscriptomicsTranscription profiling by array of human peripheral blood mononuclear cells treated with staphylococcal superantigens SEB or SEI against untreated controls
The species Staphylococcus (S.) aureus harbors 19 superantigen gene loci, six of which are located in the enterotoxin gene cluster (egc). While these egc superantigens are far more prevalent in clinical S. aureus isolates than non-egc superantigens, they are not a prominent cause of toxic shock. Mor...
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-11281 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human sebocytes (SEB-1) treated with 13-cis retinoic acid treatment
The pathogenesis of acne has been linked to multiple factors such as increased sebum production, inflammation, follicular hyperkeratinization, and the action of Propionibacterium acnes within the follicle. 13-cis Retinoic Acid (13-cis RA, isotretinoin) is the most potent agent in acne treatment. Su...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10432 | biostudies-arrayexpress
TranscriptomicsmiRNA profile of SEB-activated in vitro female C57BL/6 mouse splenocytes treated with Indole-3-carbinol (I3C) or 3,3'-diindolylmethane (DIM)
Splenocytes from female C57BL/6 mice were activated with SEB (1ug/ml) for 24 hours in 96-well plates. Control group was treated with vehicle (0.5% DMSO in media), and experimental groups were given either I3C or DIM (100uM). After 12 hours, cells were harvested and total RNA was isolated. Total RNA ...
ORGANISM(S): Mus musculus 
2014-12-20 | E-MTAB-3185 | biostudies-arrayexpress
TranscriptomicsGene Expression Changes Induced by Bacterial Superantigen, Staphylococcal Enterotoxin B
Toxic shock syndrome (TSS) is an acute, serious systemic illness caused by bacterial superantigens (BSAg). We characterized the early molecular events underlying TSS using our HLA-DR3 transgenic mouse model and studied gene expression profiling using DNA microarrays. HLA-DR3 transgenic mice were int...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-15571 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human immortalized sebocytes (SEB-1) treated with 13-cis retinoic acid to gain insights into its sebocyte-specific mechanism of action
This SuperSeries is composed of the following subset Series:; GSE10432: 13-cis retinoic acid treatment of human sebocytes (SEB-1); GSE10433: Human Skin: Before and 1 week after Isotretinoin Treatment; The pathogenesis of acne has been linked to multiple factors such as increased sebum production, in...
ORGANISM(S): Homo sapiens 
2008-04-06 | E-GEOD-10434 | biostudies-arrayexpress
TranscriptomicsAspergillus niger : Control (fructose) vs. steam-exploded sugarcane induction (SEB)
Transcriptional profiling of A. niger comparing mutant strains with the disrupted xylanolytic transcriptional activator gene, XlnR, the arabinolytic transcriptional activator gene, AraR, and the double mutant (M-NM-^TXlnR, M-NM-^TaraR and M-NM-^TaraRM-NM-^TXlnR, repsectively) treated with steam-expl...
ORGANISM(S): Aspergillus niger 
2012-05-06 | E-GEOD-37758 | biostudies-arrayexpress
GenomicsPBMCs from healthy donors and CTCL patient control vs SEB stimulation
PBMCs from healthy donors and CTCL patient control vs SEB stimulation
PRJNA756285 | ENA
GenomicsSEB Genotyping: SmartAmp-Eprimer Binary code Genotyping for complex, highly variable targets applied to HBV
SEB Genotyping - applied to HBV
PRJEB51673 | ENA
TranscriptomicsLate Multiple Organ Surge in Interferon-regulated Target Genes Characterizes Staphylococcal Enterotoxin B Lethality
Bacterial superantigens are virulence factors that cause toxic shock syndrome. Here, the genome-wide, temporal response of mice to lethal intranasal staphylococcal enterotoxin B (SEB) was investigated in six tissues (PBMC, lung, spleen, kidney, heart, Liver).The earliest responses and largest number...
ORGANISM(S): Mus musculus 
2014-03-01 | E-GEOD-52474 | biostudies-arrayexpress
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