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TranscriptomicsmiRNA alterations are an important mechanism in the adaptation of maize to a low-phosphate environment
Maize is a globally important food and feed crop, and a low-phosphate (Pi) supply in the soil frequently limits maize yield in many areas. MicroRNAs (miRNAs) play important roles in the development and adaptation of plants to the environment. In this study, the spatio-temporal miRNA transcript profi...
ORGANISM(S): Zea mays 
2015-07-08 | E-GEOD-70612 | biostudies-arrayexpress
TranscriptomicsCollection of various small RNA sequencing libraries of C. Reinhardtii.
Collection of various small RNA libraries of C. Reinhardtii sequenced using Illumina sRNA sequencing. Libraries are derived from various C. Reinhardtii genotypes (CC1883, CC4350, CC125, J), ecotypes, life cycles (Vegatative, Zygote) treatments and mutants. Preparation was done over a period of sev...
ORGANISM(S): Chlamydomonas reinhardtii 
2020-06-16 | E-MTAB-8526 | biostudies-arrayexpress
MetabolomicsHost-parasite co-metabolic activation of antitrypanosomal aminomethyl-benzoxaboroles
Recent development of benzoxaborole-based chemistry gave rise to a collection of compounds with great potential in targeting diverse infectious diseases, including human African Trypanosomiasis (HAT), a devastating neglected tropical disease. However, further medicinal development is largely restric...
2018-02-12 | MTBLS452 | MetaboLights
ProteomicsLinezolid suppresses growth of tumours dervived from triple negative breast cancer, cancer chemoresistant and cancer stem-like cells through the induction of mitochondrial dysfunction
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvirontment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC) is thought to be responsible for tumour recurrence. These consequences are fatal f...
ORGANISM(S): Homo sapiens (Human) 
2018-11-04 | PXD009442 | Pride
Autophagy Cancer stem cells Ros Cancer Therapy resistance Antibiotics Lc-ms/ms 
ProteomicsCryo-EM structures of the human Elongator complex at work
The deposited data concern the mapping of acetylation sites on wild-type and the K280A, Y363A mutants of Elp3 by LC-MS/MS. Abstract of the manuscript: tRNA modifications affect ribosomal elongation speed and co-translational folding dynamics. The Elongator complex is responsible for introducing 5-ca...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092998 | MassIVE
TranscriptomicsAlbumin, TGF-Beta1 and Blood-Brain Barrier opening induce cortical epileptogenesis.
Insults to the cerebral cortex, such as trauma, ischemia or infections, may result in the development of epilepsy, one of the most common neurological disorders. Previous studies have suggested that perturbations in neurovascular integrity and breakdown of the blood-brain barrier (BBB) lead to neuro...
ORGANISM(S): Rattus norvegicus 
2009-07-15 | E-GEOD-12304 | biostudies-arrayexpress
UnknownDevelopment and validation of a risk score for chronic kidney disease in HIV infection using prospective cohort data from the D:A:D study.
Not available
S-EPMC4380415 | biostudies-literature
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
MetabolomicsCommon Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Cancer cells are known to reprogram their metabolism to adapt to adverse conditions dictated by tumor growth and microenvironment. A subtype of cancer cells with stem-like properties, known as cancer stem cells (CSC), is thought to be responsible for tumor recurrence. In this study, we demonstrated ...
2019-08-19 | MTBLS678 | MetaboLights
TranscriptomicssmallRNA-seq of Solanum lycopersicum bearing the sulfurea epiallele in nrpe1 versus WT
Plants bearing a sulfurea epiallele (TAB2sulf) were crossed with nrpe1 (largest polV subunit) mutants in Solanum Lycopersicum. 7 plants of a F3 progeny expected to be 100% TAB2sulf and segregating for the nrpe1 mutation were sequenced. 4 plants bear the nrpe1 mutation and 3 plants have NRPE1 WT all...
ORGANISM(S): Solanum lycopersicum 
2021-07-02 | E-MTAB-10565 | biostudies-arrayexpress
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