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Proteomicsozone-derived oxisterols impair lung macrophage phagocytosis via adduction of phagocytosis receptors
Inhalation of the amibient air polution ozone causes lung inflammation and can suppress host defense mechanisms, including impairing macrophage phagocytosis. Ozone reacts with cholesterol in the lung to form oxysterols, like secosterol A and secosterol B, which can form covalent adducts on cellular ...
ORGANISM(S): Homo sapiens (Human) 
2020-07-18 | PXD019317 | Pride
Lung macrophage Bronchoalveolar lavage Click Secosterol a/b Ozone Human Cd206 
UnknownCholesterol secosterol aldehyde adduction and aggregation of Cu,Zn-superoxide dismutase: Potential implications in ALS.
Not available
S-EPMC6106709 | biostudies-literature
UnknownInhibition of endothelial- and neuronal-type, but not inducible-type, nitric oxide synthase by the oxidized cholesterol metabolite secosterol aldehyde: Implications for vascular and neurodegenerative diseases.
Not available
S-EPMC3246188 | biostudies-literature
UnknownCholesterol secosterol aldehydes induce amyloidogenesis and dysfunction of wild-type tumor protein p53.
Not available
S-EPMC3148486 | biostudies-literature
ProteomicsOxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.
Ozone (O3) is a prevalent air pollutant that causes lung inflammation following exposure. Previous studies demonstrate that O3 oxidizes lipids, such as cholesterol, in the airway to produce oxidized cholesterol products (oxysterols), such as secosterol-A (secoA), which form covalent linkages prefere...
ORGANISM(S): Homo sapiens (Human) 
2021-06-21 | PXD019824 | Pride
Human Lc-msms Airway epithelium Lung inflammasome Alkynylated secosterol Click Protein modification Ozone Secosterols 
UnknownVitamin D5 in Arabidopsis thaliana.
Not available
S-EPMC6218535 | biostudies-literature
UnknownOzone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors.
Not available
S-EPMC7476716 | biostudies-literature
UnknownMass spectrometry dataset on apo-SOD1 modifications induced by lipid aldehydes.
Not available
S-EPMC7316990 | biostudies-literature
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