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MetabolomicsTargeting secreted MDK-mediated tryptophan/kynurenine metabolism enhances DLL3 CAR T therapy for SCLC

Small cell lung cancer (SCLC) exhibits profound immunometabolic suppression that impairs antigen presentation and constrains immunotherapy efficacy. Through integrated multi-omics analyses of primary human SCLC tumors, we identified midkine (MDK) as a dominant tumor-secreted driver of immune evas...

2026-03-23 | MTBLS14116 | MetaboLights
ProteomicsSecreted HLA Fc-Fusion Profiles Immunopeptidome in Hypoxic PDAC and Cellular Senescence
Here, we describe a secreted HLA (sHLA) Fc-fusion construct for simple single HLA allele profiling in hypoxic pancreatic ductal adenocarcinoma (PDAC) and cellular senescence. This method streamlines sample preparation, enables temporal control, and provides allele-restricted target identification. O...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD045796 | Pride
Immunopeptidomics Senescence Secreted hla Hypoxia 
ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum 
2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress
UnknownSecreted HLA-Fc fusion profiles immunopeptidome in hypoxic PDAC and cellular senescence.
Not available
S-EPMC10720946 | biostudies-literature
TranscriptomicsBone marrows infiltrating human neuroblastoma cells express high levels of calprotectin and HLA-G proteins.
In neuroblastoma (NB) patients metastasis are the main cause of death, thus understanding the biological and genetic features of the metastatic NB cells is needed to reach efficient target-based therapies for high risk patients. In recent years, several prognostic signatures derived from gene expres...
ORGANISM(S): Homo sapiens 
2012-01-20 | E-GEOD-25623 | biostudies-arrayexpress
TranscriptomicsImmune related gene expression comparison between human CD14+ HLA-DR-neg/low MDSC vs CD14+ HLA-DR-high control monocytes
Myeloid-derived suppressor cells (MDSC) is a heterogeneous population of cells that can negatively regulate T-cell function. As opposed to murine MDSC, which are characterized as Gr-1+CD11b+ cells, human MDSC are not so clearly defined due to lack of specific markers. Our lab has previously identifi...
ORGANISM(S): Homo sapiens 
2011-09-08 | E-GEOD-32001 | biostudies-arrayexpress
TranscriptomicsCD8 T cells cross-restricted by HLA-B*57 and HLA-E*01 recognize HIV Gag with different functional profiles [dataset 1]
Few non-classical HLA-E restricted HIV-specific epitopes have been described, and even less is known about the functional profile of responding CD8 T cells (CD8s). This study evaluates the functional characteristics of CD8s targeting the Gag epitope (KAFSPEVIPMF or KF11) based on their restriction b...
ORGANISM(S): Homo sapiens 
2025-12-11 | GSE306022 | GEO
TranscriptomicsCD8 T cells cross-restricted by HLA-B*57 and HLA-E*01 recognize HIV Gag with different functional profiles [dataset 2]
Few non-classical HLA-E restricted HIV-specific epitopes have been described, and even less is known about the functional profile of responding CD8 T cells (CD8s). This study evaluates the functional characteristics of CD8s targeting the Gag epitope (KAFSPEVIPMF or KF11) based on their restriction b...
ORGANISM(S): Homo sapiens 
2025-12-11 | GSE306023 | GEO
UnknownThe serodominant secreted effector protein of Salmonella, SseB, is a strong CD4 antigen containing an immunodominant epitope presented by diverse HLA class II alleles.
Not available
S-EPMC4212957 | biostudies-literature
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