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Deciphering the mode of action (MOA) of new antibiotics discovered through phenotypic screening is of increasing importance. Metabolomics offers a potentially rapid and cost-effective means of identifying modes of action of drugs whose effects are mediated through changes in metabolism. Metabolomics...
2017-06-16 | MTBLS464 | MetaboLights
We used DNA microarrays to characterize gene expression patterns in skin biopsies from individuals with a diagnosis of systemic sclerosis with diffuse scleroderma and compared those to the patterns of gene expression seen in biopsies from normal, unaffected individuals.
ORGANISM(S): Homo sapiens 
Reed2004 - Methionine Cycle This model is described in the article: A mathematical model of the methionine cycle. Reed MC, Nijhout HF, Sparks R, Ulrich CM. J. Theor. Biol. 2004 Jan; 226(1): 33-43 Abstract: Building on the work of Martinov et al. (2000), a mathem...
2024-09-02 | BIOMD0000000698 | BioModels
DNA methylation is a defining feature of mammalian cellular identity and is essential for normal development. Most cell types, except germ cells and pre-implantation embryos, display relatively stable DNA methylation patterns, with 70-80% of all CpGs being methylated. Despite recent advances we stil...
ORGANISM(S): Homo sapiens 
Interferon-gamma (IFN-gamma) is approved as a drug to treat chronic granulomatous disease and osteopetrosis and is also used in hyperimmunoglobulin E syndromes. These primary immunodeficiencies involve defects in neutrophils/polymorphonuclear cells. Neutrophils mature in the bone marrow and then e...
ORGANISM(S): Homo sapiens 
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