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TranscriptomicsTime course of oxidative stress responses in yeast, caused by Menadione or hydrogen peroxide
Oxidative stress caused by Menadione or Hydrogen peroxide in synchronized Saccharomyces cerevisiae cultures. Alpha factor synchronized cultures (0.2-0.4 OD), treated at the beginning of S phase (25 min after release from G1 arrest) with either 2 mM Menadione (MD) or 0.24 mM Hydrogen peroxide (HP), s...
ORGANISM(S): Saccharomyces cerevisiae 
2005-02-04 | E-GEOD-2239 | biostudies-arrayexpress
TranscriptomicsModule map of stem cell genes guides creation of epithelial cancer stem cells
Self-renewal is a hallmark of stem cells and cancer, but existence of a shared stemness program remains controversial. Here we construct a gene module map to systematically relate transcriptional programs in embryonic stem cells (ESCs), adult tissue stem cells, and human cancers. This map reveals tw...
ORGANISM(S): Homo sapiens 
2008-04-10 | E-GEOD-10423 | biostudies-arrayexpress
GenomicsA genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture
Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided nucleases have gathered considerable excitement as a tool for genome engineering. However, questions remain about the specificity of their target site recognition. Most previous studies have examined predicted off-target bi...
ORGANISM(S): Homo sapiens 
2015-03-04 | E-GEOD-61099 | biostudies-arrayexpress
UnknownEffect of mesenchymal stromal cell infusions on lung function in COPD patients with high CRP levels.
Not available
S-EPMC8106850 | biostudies-literature
UnknownDivergent Outcomes in Cognitive-Behavioral Therapy and Pharmacotherapy for Adult Depression.
Not available
S-EPMC4934129 | biostudies-literature
TranscriptomicsUsing breast (cancer) cell lines to measure bortezomib therapy response
Revealing targeted therapy for human cancer by gene module maps A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-5307 | biostudies-arrayexpress
UnknownSerine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers.
Not available
S-EPMC10620120 | biostudies-literature
TranscriptomicsA Gene Expression Signature for Insulin Resistance
Insulin resistance is a heterogeneous disorder caused by a range of genetic and environmental factors, and we hypothesise that its aetiology varies considerably between individuals. This heterogeneity provides significant challenges to the development of effective therapeutic regimes for long-term m...
ORGANISM(S): Mus musculus 
2010-09-10 | E-GEOD-18103 | biostudies-arrayexpress
UnknownIn Vitro and In Vivo Therapeutic Potential of 6,6'-Dihydroxythiobinupharidine (DTBN) from Nuphar lutea on Cells and K18-hACE2 Mice Infected with SARS-CoV-2.
Not available
S-EPMC10179516 | biostudies-literature
UnknownTo Expand the Evidence Base About Harms from Tests and Treatments.
Not available
S-EPMC8298733 | biostudies-literature
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