Sort   by:  
 Page size 
TranscriptomicsTime course of oxidative stress responses in yeast, caused by Menadione or hydrogen peroxide
Oxidative stress caused by Menadione or Hydrogen peroxide in synchronized Saccharomyces cerevisiae cultures. Alpha factor synchronized cultures (0.2-0.4 OD), treated at the beginning of S phase (25 min after release from G1 arrest) with either 2 mM Menadione (MD) or 0.24 mM Hydrogen peroxide (HP), s...
ORGANISM(S): Saccharomyces cerevisiae 
2005-02-04 | E-GEOD-2239 | biostudies-arrayexpress
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsCoupling p53 binding and nucleosome occupancy measurements at p53 binding sites
We were interested to explain why p53 binds some high affinity sites in contrast to other high affinity sites that are not bound by p53. p53 binding was measured using p53 ChIP-CHIP and in parallel nucleosome occupancy was measured on these same sites Comparison between p53 binding and nucleosome oc...
ORGANISM(S): Homo sapiens 
2010-08-09 | E-GEOD-22783 | biostudies-arrayexpress
TranscriptomicsGenome-wide Measurement of RNA Secondary Structure in Yeast
The structures of RNA molecules are often important for their function and regulation, yet there are no experimental techniques for genome-scale measurement of RNA structure. Here, we describe a novel strategy termed Parallel Analysis of RNA Structure (PARS), which is based on deep sequencing fragme...
ORGANISM(S): Saccharomyces cerevisiae 
2010-08-24 | E-GEOD-22393 | biostudies-arrayexpress
GenomicsGenome-wide nucleosome occupancy profiling by high throughput sequencing, and microarray analysis of RNA abundance
We profiled nucleosome occupancy of different developmental stages in C. elegans. Mononucleosomal DNA was sequenced by Illumina paired-end sequencing. We used embryos, germlineless adults, germ line containing adults, and XO hermaphrodites at L3 larval stage. RNA abundance is determined by microarra...
ORGANISM(S): Caenorhabditis elegans 
2010-03-02 | E-GEOD-20136 | biostudies-arrayexpress
TranscriptomicsUsing breast (cancer) cell lines to measure bortezomib therapy response
Revealing targeted therapy for human cancer by gene module maps A major goal of cancer research is to match specific therapies to molecular targets in cancer. Genome-scale expression profiling has identified new subtypes of cancer based on consistent patterns of variation in gene expression, leading...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-5307 | biostudies-arrayexpress
TranscriptomicsInferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters
Despite extensive research, our understanding of the rules according to which cis-regulatory sequences are converted into gene expression is limited We devised a method for obtaining parallel, highly accurate gene expression measurements from thousands of designed promoters and applied it to measure...
ORGANISM(S): Saccharomyces cerevisiae 
2012-05-20 | E-GEOD-37851 | biostudies-arrayexpress
TranscriptomicsGenome-wide measurement of RNA folding energies
RNA structural transitions are important in the function and regulation of RNAs. Here, we reveal a layer of transcriptome organization in the form of RNA folding energies. By probing yeast RNA structures at different temperatures, we obtained relative melting temperatures (Tm) for RNA structures in ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-09-09 | E-GEOD-39680 | biostudies-arrayexpress
GenomicsSerum Metabolomics Data Access Committee
Data Access Committee EGAC00001001645
EGAC00001001645 | EGA
GenomicsHuman Phenotype project Data Access Commitee
Data Access Committee EGAC00001003214
EGAC00001003214 | EGA
Sort   by:  
 Page size