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MetabolomicsSeipin Governs Caveolin-1 Trafficking Through Modulating Sphingolipid-Glycerolipid Balance

Dysregulation of Caveolin-1 (CAV1), a key component of caveolae, leads to pleiotropic disorders; yet, the mechanisms controlling its trafficking remain unclear. Here, we show that the lipid droplet (LD) biogenesis factor seipin controls CAV1 localization. Seipin deficiency in mice and HeLa cells ...

2025-07-22 | MTBLS12759 | MetaboLights
ProteomicsDeficiency of the ER protein seipin results in generalised lipodystrophy by incompletely understood mechanisms. Here, we report mitochondrial abnormalities in seipin deficient patient cells.Seipin localizes at endoplasmic reticulum-mitochondria contact sites to control mitochondrial calcium import and metabolism in adipocytes
Deficiency of the ER protein seipin results in generalised lipodystrophy by incompletely understood mechanisms. Here, we report mitochondrial abnormalities in seipin deficient patient cells. A subset of seipin is enriched at ER-mitochondria contact sites (MAMs) in human and mouse cells and localizes...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-18 | PXD029637 | Pride
Ap-ms Mus musculus Seipin Calcium handling Adipocyte Orbitrap fusion Bottom-up Mams Mitochondria dysfunction 
ProteomicsWT and N88S seipin-expressing cells proteomic profilling
WT and N88S seipin-expressing cells were grown in SC-glucose medium to post-diauxic shift (PDS) phase. We intend to evaluate differentially expressed proteins (DEPs) between the two strains. Three biological replicates (classified as 1-3 for the corresponding strain) were used per strain.
ORGANISM(S): Saccharomyces cerevisiae Saccharomyces cerevisiae (Baker's yeast) 
2024-09-23 | PXD054826 | Pride
Seipin Misfolding Seipinopathy Yeast systems biology 
GenomicsLoss of the seipin gene perturbs eggshell formation in Caenorhabditis elegans
Loss of the seipin gene perturbs eggshell formation in Caenorhabditis elegans
PRJNA663023 | ENA
UnknownMolecular characterization of seipin and its mutants: implications for seipin in triacylglycerol synthesis.
Not available
S-EPMC3220282 | biostudies-literature
GenomicsWT and N88S seipin-expressing cells upon bathophenanthrolinedisulfonate (BPS) treatment
WT and N88S seipin-expressing cells upon bathophenanthrolinedisulfonate (BPS) treatment
PRJNA1144137 | ENA
UnknownSeipin is a discrete homooligomer.
Not available
S-EPMC3086013 | biostudies-literature
TranscriptomicsRNA sequencing of inguinal white adipose tissue from seipin-deficient mice and appropriate controls
We generated Bscl2lox/lox mice X ERT2-Adipoq-CRE mice, allowing inducible seipin deletion in adipocytes upon tamoxifen addition (iATSKO). Indeed, a 5-day tamoxifen treatment led to a dramatic decrease in Bscl2 mRNA in the adipose tissue. To study the effects of seipin deficiency in vivo on adipose t...
ORGANISM(S): Mus musculus 
2022-01-11 | GSE188544 | GEO
GenomicsRNA sequencing of inguinal white adipose tissue from seipin-deficient mice and appropriate controls
RNA sequencing of inguinal white adipose tissue from seipin-deficient mice and appropriate controls
PRJNA779393 | ENA
UnknownPromethin Is a Conserved Seipin Partner Protein.
Not available
S-EPMC6468817 | biostudies-literature
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