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TranscriptomicsTranscriptional response to stress in serum deprived mouse fibroblasts [RNA-Seq]
We have employed gene expression profiling in order to identify targets of transcriptional response to stress in resting mouse Swiss 3T3 fibroblasts, either untreated (control) or treated with anisomycin to induce the p38/MAP kinase pathway. Serum starved (72 h 0.2% FCS) mouse 3T3 cells were treated...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-55776 | biostudies-arrayexpress
GenomicsStress-induced signaling to the nucleosome in serum deprived mouse fibroblasts.
We have employed chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) to analyze changes in chromatin architecture as well as the occupancy of two RNA Polymerase II (RNAPII) isoforms, initiation-competent (RNAPIIS5ph) as well as elongation-competent (RNAPIIS2ph) upon stres...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-55774 | biostudies-arrayexpress
TranscriptomicsTranscriptional response to stress in serum deprived mouse fibroblasts in the presence of MSK1/2 inhibitor.
We have employed gene expression profiling in order to identify targets of transcriptional response to stress in resting mouse Swiss 3T3 fibroblasts, either untreated (control) or treated with anisomycin for 3 or 6 hours to induce the p38/MAP kinase pathway. In order determine transcriptional effec...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-58746 | biostudies-arrayexpress
TranscriptomicsPromoter proximal pausing in response to stress in serum deprived mouse fibroblasts.
We have employed short-capped RNA sequencing (sc-RNA-seq) in order to identify genes whose expression is regulated by promoter proximal pausing of RNA Polymerase II (RNAPI) in response to stress stimulation. We used serum-deprived mouse Swiss 3T3 fibroblasts, either untreated (control) or treated wi...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-55775 | biostudies-arrayexpress
ProteomicsRegulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases
Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD030164 | Pride
Acetylome Chromatin Hdac inhibitor Histone deacetylase 
TranscriptomicsTranscriptional response to stress in serum deprived mouse fibroblasts
We have employed gene expression profiling in order to identify targets of transcriptional response to stress in mouse Swiss 3T3 fibroblasts, where we induced p38/MAP kinase pathway using anisomycin. Serum starved (72 h) mouse 3T3 cells were treated with anisomycin (188.5 nM) for 1, 3, and 6 h (in t...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-55554 | biostudies-arrayexpress
Unknown14-3-3 proteins recognize a histone code at histone H3 and are required for transcriptional activation.
Not available
S-EPMC2206135 | biostudies-literature
ProteomicsPotential effect of L1TD1 on proteomics in HAP1 cells
L1TD1 is a domesticated transposon protein which a RNA-binding capacity. In this project, we aim to investigate the mechanisms through which L1TD1 acts on its RNA targets. First, we first aim to identify the de novo RNA targets of L1TD1 and then is to analyze how proteomics and transcriptomics chang...
ORGANISM(S): Homo sapiens (Human) 
2025-02-11 | PXD047402 | Pride
Hap1 cells Rna-binding protein Stability 
UnknownFunctional Recovery in Autoimmune Encephalitis: A Prospective Observational Study.
Not available
S-EPMC8175889 | biostudies-literature
TranscriptomicsHDAC1/2 and CD4+ T cells
Dynamic changes in histone acetylation patterns are mediated by the activity of histone acetyltransfereases (HATs) and histone deacetylases (HDACs) and are key events in the epigenetic regulation of gene expression. The application of HDAC inhibitors revealed a variety of T cell functions controlled...
ORGANISM(S): Mus musculus 
2014-03-30 | E-MTAB-2184 | biostudies-arrayexpress
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