Sort   by:  
 Page size 
ProteomicsDon’t die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
A hallmark of Parkinson’s disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are equally affected. Studies revealed that neurons located more ventrally within the substantia nigra pars compacta have a higher pre...
ORGANISM(S): Homo sapiens (Human) 
2024-08-09 | PXD037696 | Pride
Neurons Mass spectrometry Proteomic Selective neuronal vulnerability Substantia nigra 
GenomicsPathways underlying selective neuronal vulnerability in Alzheimer's disease: contrasting the vulnerable locus coeruleus to the resilient substantia nigra
Pathways underlying selective neuronal vulnerability in Alzheimer's disease: contrasting the vulnerable locus coeruleus to the resilient substantia nigra
PRJNA1143056 | ENA
TranscriptomicsPathways underlying selective neuronal vulnerability in Alzheimer's disease: contrasting the vulnerable locus coeruleus to the resilient substantia nigra
Identifying factors underlying selective neuronal vulnerability is crucial for understanding Alzheimer's disease (AD) pathophysiology. The Neuromodulatory Subcortical System (NSS) includes nuclei that exhibit early, but varied vulnerability to tau accumulation and neuronal loss. This varied vulnerab...
ORGANISM(S): Homo sapiens 
2025-03-26 | GSE273787 | GEO
TranscriptomicsSelective loss of 5hmC links to A-T Purkinje cell vulnerability
This SuperSeries is composed of the SubSeries listed below. The neurodegenerative disease known as ataxia-telangiectasia (A-T) is caused by the absence of the ATM (A-T mutated) protein. A long-standing mystery surrounding A-T is why cerebellar Purkinje cells (PCs) appear uniquely vulnerable to ATM-...
ORGANISM(S): Homo sapiens 
2015-10-30 | E-GEOD-61169 | biostudies-arrayexpress
UnknownSelective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis.
Not available
S-EPMC7580783 | biostudies-literature
UnknownCell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Not available
S-EPMC5785690 | biostudies-literature
GenomicsIntracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease
Intracellular accumulation of amyloid-ß is a marker of selective neuronal vulnerability in Alzheimer’s disease
PRJNA1262360 | ENA
UnknownDon't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
Not available
S-EPMC11290673 | biostudies-literature
UnknownGenomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress.
Not available
S-EPMC2677396 | biostudies-literature
TranscriptomicsComparison of gene expression in motor pools with differential vulnerability in ALS
ALS is a uniformly fatal neurodegenerative disease in which motor neurons in the spinal cord and brain stem are selectively lost. Individual motor - groups of motor neurons innervating single muscles - show widely varying degrees of disease resistance: in the final stages of ALS, nearly all voluntar...
ORGANISM(S): Mus musculus 
2013-11-15 | E-GEOD-52118 | biostudies-arrayexpress
Sort   by:  
 Page size