Sort   by:  
 Page size 
ProteomicsHigh-dose oncogenic PIK3CA drives constitutive cellular stemness through increased NODAL/TGFb signaling
Oncogenic PIK3CA mutations activate phosphoinositide 3-kinase (PI3K) and are among the commonest somatic mutations in cancer and mosaic, developmental overgrowth disorders. We recently demonstrated that the ‘hotspot’ variant PIK3CAH1047R exerts striking allele dose-dependent effects on stemness in h...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD014719 | Pride
Proteomics Tfgb Nodal ipsc Cancer Transcriptomics Pik3ca 
UnknownA companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3-WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force.
Not available
S-EPMC12375983 | biostudies-literature
UnknownA companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3-WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force.
Not available
S-EPMC12375966 | biostudies-literature
UnknownHypomorphism in human NSMCE2 linked to primordial dwarfism and insulin resistance.
Not available
S-EPMC4151221 | biostudies-literature
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Human data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2015-10-05 | MTBLS162 | MetaboLights
MetabolomicsMechanistic insights revealed by lipid profiling in monogenic insulin resistance syndromes (Mouse data)
Evidence from several recent metabolomic studies suggests that increased concentrations of triacylglycerols (TAGs) with shorter (14-16 carbon atoms), saturated fatty acids are associated with insulin resistance and the risk of type 2 diabetes. Although causality cannot be inferred from association s...
2017-03-02 | MTBLS327 | MetaboLights
UnknownMulticenter Safety and Practice for Off-Label Diagnostic Use of Ferumoxytol in MRI.
Not available
S-EPMC6884068 | biostudies-literature
UnknownHeterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.
Not available
S-EPMC3928658 | biostudies-literature
UnknownClinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities.
Not available
S-EPMC8354853 | biostudies-literature
UnknownDiscovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network.
Not available
S-EPMC8172540 | biostudies-literature
Sort   by:  
 Page size