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TranscriptomicsExpression data from young and senescent HCAECs treated with proton pump inhibitors (omeprazole and lansoprazole)
Proton pump inhibitors (PPIs) are among the most frequently prescribed drugs, especially in older people. Although these drugs are usually considered safe, recent evidence suggests that high dose and/or long term use of PPIs may have several detrimental effects, including increased risk of adverse c...
ORGANISM(S): Homo sapiens 
2017-04-18 | E-GEOD-77239 | biostudies-arrayexpress
TranscriptomicsGene Expression Data from Senescent vs Non-senescent Cells in the in Vivo Human Annulus
The presence of senescent cells in the aging/degenerating human disc is now well-recognized. Senescent cells are viable, cannot divide, remain metabolically active and accumulate within the disc over time. Molecular analysis of senescent cells in tissue, however, offers a special challenge since the...
ORGANISM(S): Homo sapiens 
2009-07-15 | E-GEOD-17077 | biostudies-arrayexpress
GenomicsGenome-wide methylation maps for Proliferating and Senescent cells
Altered DNA methylation and associated destabilization of genome integrity and function is a hallmark of cancer. Replicative senescence imposes a limit on proliferative potential that all cancer cells must bypass. Compared to proliferating cells, senescent cells exhibit marked chromatin re-organizat...
ORGANISM(S): Homo sapiens 
2013-11-25 | E-GEOD-48580 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human young and senescent HUVECs under static and laminar shear stress conditions
Laminar shear stress due to constant blood flow is known to play a critical role in maintaining vascular health. In contrast, endothelial cell senescence appears to be closely associated with the incidence of vascular disorder. In an attempt to identify functional biomarkers for age-related vascular...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-13712 | biostudies-arrayexpress
MetabolomicsAMPK activation orchestrated replicative senescence of periodontal ligament stem cells via regulating metabolomics

BACKGROUND: Periodontal ligament mesenchymal stem cells (PDLSCs) are a promising cell resource for cell-based regenerative medicine in dentistry. PDLSCs inevitably acquire a senescent phenotype after prolonged in vitro expansion, and the key regulators of cells during replicative...

2022-11-15 | MTBLS4568 | MetaboLights
TranscriptomicsHigh-throughput sequencing of AGO-immunoprecipitating miRs in human senescent fibroblast WI-38
In humans, there are four Ago proteins (Ago1M-bM-^@M-^S4) and AGO1- and 2 were previously implicated in TGS induced by exogenous siRNAs and microRNAs (miRs) directed against gene promoter transcripts via promotion of changes in histone covalent modifications and DNA methylation. Not-with-standing, m...
ORGANISM(S): Homo sapiens 
2011-12-17 | E-GEOD-34494 | biostudies-arrayexpress
TranscriptomicsRNA-seq of young and senescent human umbilical vein endothelial cells (HUVECs) under normal or high glucose conditions
Human endothelial cellular models are useful to disentangle the pathophysiological role of dysfunctional endothelium in the development of cardiovascular (CV) disease and organ damage in T2D. Here, we performed a RNAseq of human umbilical vein endothelial cells (HUVECs) undergoing replicative senesc...
ORGANISM(S): Homo sapiens 
2024-04-08 | E-MTAB-13959 | biostudies-arrayexpress
ProteomicsProteome of senescent human lung fibroblasts and Panc-1 cells
Proteomic analysis of proliferating and senescent normal healthy lung fibroblasts (NHLFs) and Panc-1 cells. Senescence was induced using 5 uM Palbociclib for 6 days. Cells were lysed in SDS lysis buffer (2% SDS in 100 mM TEAB), boiled (15 min, 95 °C, 500 rpm) and sonicated in a sonication bath (10 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-10-28 | MSV000090607 | MassIVE
TranscriptomicsMicroarray data for rejuvenation experiments through reprogramming
Proliferative and replicative senescent fibroblasts from aged human donors were reprogrammed towards pluripotency and re-differentiated in fibroblasts and then further analyzed for rejuvenation assessment. Comparison of microarrays were performed by non hierarchical clustering visualized in with Tre...
ORGANISM(S): Homo sapiens 
2011-12-14 | E-GEOD-27924 | biostudies-arrayexpress
ProteomicsMyeloma cancer cells can corrupt mesenchymal stromal senescent cells and impair their anti-tumor activity
Senescent cells secrete many molecules, which contribute to the prevention of cancer progression. We induced MSC senescence by oxidative stress, DNA damage, and replicative exhaustion. The first two are considered inducers of acute senescence while extensive proliferation triggers replicative senesc...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003018 | Pride
Mesenchymal stem cells  senescence  secretome  apoptosis  cancer 
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