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ProteomicsComparative ploidy proteomics of Candida albicans biofilms unraveled the role of AHP1 in the biofilm persistence against amphotericin B
To understand the molecular mechanism operating in the biofilm mode of growth of C. albicans haploids, we performed an iTRAQ-based mass spectrometry profiling of proteins of 72 h mature biofilms of the two haploids, GZY792 and GZY803 compared to that of the diploids, SC5314 and BWP17.
ORGANISM(S): Candida albicans (Yeast) 
2016-09-27 | PXD004274 | Pride
Candida albicans Proteomics Antifungals Ahp1 Biofilms 
ProteomicsCaspofungin-induced Responses in the Planktonic Cells and Biofilms of Candida albicans
This project investigated the signature profiles of C. albicans planktonic cells and biofilms in response to caspofungin.
ORGANISM(S): Candida Albicans 
2021-01-08 | PXD023480 |
UnknownUse of Haploid Model of Candida albicans to Uncover Mechanism of Action of a Novel Antifungal Agent.
Antifungal agents for the treatment of Candida albicans infections are limited. We recently discovered a novel antifungal small molecule, SM21, with promising in vivo activity. Herein, we employed the newly developed C. albicans haploid toolbox to uncover the mechanism of action...
S-EPMC6002804 | biostudies-literature
UnknownNew "haploid biofilm model" unravels IRA2 as a novel regulator of Candida albicans biofilm formation.
Clinical isolates of the fungal human pathogen Candida albicans are invariably diploid and heterozygous, impeding genetic study. Recent isolation of C. albicans haploids opens opportunities to apply technologies unfeasible in diploids. However, doubts remain on whether the haploids, derived from chr...
S-EPMC5378891 | biostudies-literature
ProteomicsEnterococcus faecalis biofilm proteome
The biofilm proteome profile of endodontic and systemic pathogen E. faecalis has been analysed in this study to identify markers associated with its biofilm formation. Strong and weak biofilm forming E. faecalis clinical isolates were compared with two standard ATCC strains of E. faecalis in order t...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2018-01-29 | PXD006542 | Pride
Enterococcus faecalis Biofilm Proteome Itraq 
ProteomicsProteomic analysis of Candida albicans dnm1 mutant
Proteomic analysis of Candida albicans haploid dnm1 mutant and the wild type GZY803
ORGANISM(S): Candida albicans (Yeast) 
2019-12-13 | PXD008834 | Pride
Candida albicans Dnm1 Itraq 
UnknownSdd3 regulates the biofilm formation of <i>Candida albicans</i> via the Rho1-PKC-MAPK pathway.
Candida albicans, the most frequently isolated fungal pathogen in humans, forms biofilms that enhance resistance to antifungal drugs and host immunity, leading to frequent treatment failure. Understanding the molecular mechanisms governing biofilm formation is crucial for developing anti-biof...
S-EPMC11796410 | biostudies-literature
UnknownFactors associated with D-dimer levels in HIV-infected individuals.

Background

Higher plasma D-dimer levels are strong predictors of mortality in HIV+ individuals. The factors associated with D-dimer levels during HIV infection, however, remain poorly understood.

Methods

In this cross-sectional study, participants in three randomized controlled trials...
S-EPMC3953205 | biostudies-literature
UnknownDe Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.
Next-generation sequencing has been invaluable in the elucidation of the genetic etiology of many subtypes of intellectual disability in recent years. Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in ...
S-EPMC6037130 | biostudies-literature
UnknownBiallelic Mutation of ARHGEF18, Involved in the Determination of Epithelial Apicobasal Polarity, Causes Adult-Onset Retinal Degeneration.
Mutations in more than 250 genes are implicated in inherited retinal dystrophy; the encoded proteins are involved in a broad spectrum of pathways. The presence of unsolved families after highly parallel sequencing strategies suggests that further genes remain to be identified. Whole-exome and -genom...
S-EPMC5294887 | biostudies-literature
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