Proteomics

Dataset Information

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Comparative ploidy proteomics of Candida albicans biofilms unraveled the role of AHP1 in the biofilm persistence against amphotericin B


ABSTRACT: To understand the molecular mechanism operating in the biofilm mode of growth of C. albicans haploids, we performed an iTRAQ-based mass spectrometry profiling of proteins of 72 h mature biofilms of the two haploids, GZY792 and GZY803 compared to that of the diploids, SC5314 and BWP17.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Candida Albicans (yeast)

SUBMITTER: Thuyen Truong  

LAB HEAD: Dr. C. J. Seneviratne

PROVIDER: PXD004274 | Pride | 2016-09-27

REPOSITORIES: Pride

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Publications

Comparative Ploidy Proteomics of Candida albicans Biofilms Unraveled the Role of the AHP1 Gene in the Biofilm Persistence Against Amphotericin B.

Truong Thuyen T   Zeng Guisheng G   Qingsong Lin L   Kwang Lim Teck LT   Tong Cao C   Chan Fong Yee FY   Wang Yue Y   Seneviratne Chaminda Jayampath CJ  

Molecular & cellular proteomics : MCP 20160919 11


Candida albicans is a major fungal pathogen causing lethal infections in immunocompromised patients. C. albicans forms antifungal tolerant biofilms contributing significantly to therapeutic failure. The recently established haploid C. albicans biofilm model provides a new toolbox to uncover the mechanism governing the higher antifungal tolerance of biofilms. Here, we comprehensively examined the proteomics and antifungal susceptibility of standard diploid (SC5314 and BWP17) and stable haploid (G  ...[more]

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