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MetabolomicsDelineating molecular regulatory network of meat quality of longissimus dorsi indicated by transcriptomic, proteomic, and metabolomics analysis in rabbit (SPME-GC-MS assay)

This study aims to investigate the potential regulatory network responsible for the meat quality using multi-omics to help developing better varieties. Slaughter performance and meat quality of Shuxing No.1 rabbit outperformed Yila rabbit. Differentially expressed genes (DEGs) and differentially ...

2024-01-18 | MTBLS8958 | MetaboLights
TranscriptomicsQuantitative proteomic analysis reveals maturation as a mechanism underlying glucocorticoid resistance in B lineage ALL and JNK inhibitors as a re-sensitising therapy
Glucocorticoids (GC) are pivotal in the treatment of childhood acute lymphoblastic leukaemia (ALL) but resistance is a continuing clinical problem with the underlying mechanisms still unclear. An isobaric tag proteomic approach was used to compare protein profiles of the B lineage ALL GC-sensitive c...
ORGANISM(S): Homo sapiens 
2015-09-02 | E-GEOD-63335 | biostudies-arrayexpress
MetabolomicsDelineating molecular regulatory network of meat quality of longissimus dorsi indicated by transcriptomic, proteomic, and metabolomics analysis in rabbit (UPLC-MS/MS assays)

This study aims to investigate the potential regulatory network responsible for the meat quality using multi-omics to help developing better varieties. Slaughter performance and meat quality of Shuxing No.1 rabbit outperformed Yila rabbit. Differentially expressed genes (DEGs) and differentially ...

2024-01-18 | MTBLS8957 | MetaboLights
ProteomicsOptimization of data-independent acquisition-MS for deep proteome analysis
Data-independent acquisition (DIA)-MS analysis overtops the existing data-dependent acquisition (DDA)-MS analysis enabling deep proteome coverage and precise relative quantitative analysis in single-shot LC-MS/MS. We constructed a single-shot LC-MS/MS system with an MS measurement time of 90 min for...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms Mus Musculus (mouse) 
2019-10-28 | PXD016032 | JPOST Repository
ProteomicsRapid High-pH Reverse Phase StageTip for Sensitive Small-Scale Membrane Proteomic Profiling
To increase the coverage of membrane protein identification,we developed high-pH reverse phase (Hp-RP) combined with stop-and-go extraction tip (StageTip) technique, as a fast (∼15 min.). Almost 5000 proteins (∼60% membrane proteins) can be identified in only 10 μg of membrane protein digests, showi...
ORGANISM(S): Homo Sapiens (human) 
2016-09-08 | PXD004904 | JPOST Repository
ProteomicsRapid High-pH Reverse Phase StageTip for Sensitive Small-Scale Membrane Proteomic Profiling
Membrane proteins are crucial targets for cancer biomarker discovery and drug development. However, in addition to the inherent challenges of hydrophobicity and low abundance, complete membrane proteome coverage of clinical specimen is usually hindered by the requirement of large amount of starting ...
ORGANISM(S): Rattus rattus (Black rat) Homo sapiens (Human) 
2015-11-16 | PXD001548 | Pride
High-ph reverse phase stagetip Membrane proteins Lung cancer 
TranscriptomicsRNA-seq analysis of acute Rb1 deletion in adult mouse tissues
Abstract:The pRb tumor suppressor protein associates with chromatin and regulates gene expression. Numerous studies have identified Rb-dependent RNA signatures, but the proteomic effects of Rb-loss are largely unexplored. We have acutely ablated Rb in adult mice and conducted quantitative analysis o...
ORGANISM(S): Mus musculus 
2015-09-11 | E-GEOD-71924 | biostudies-arrayexpress
TranscriptomicsIntegrative transcriptomic and proteomic analysis of osteocytic cells exposed to fluid flow reveals novel mechano-sensitive signaling pathways
Osteocytes, positioned within bone’s interstitial space, are subject to fluid flow upon whole bone loading. Such fluid flow is widely theorized to be a mechanical signal transduced by osteocytes, initiating a poorly understood cascade of signaling events mediating bone metabolism. The objective ...
ORGANISM(S): Mus musculus 
2013-07-01 | E-GEOD-42874 | biostudies-arrayexpress
TranscriptomicsmiRNA profiling of mixoid liposarcoma cell lines sensitive and resistant to trabectidin
This investigation aims at identifying differentially expressed miRNA between two cell lines, MLS 402-91 (sensitive to trabectidin) and MLS 402-91/ET (resistant to trabectidin).
ORGANISM(S): Homo sapiens 
2012-06-05 | E-MTAB-695 | biostudies-arrayexpress
ProteomicsOVERDRIVE: overcoming cancer cell resistance to drugs by supplementary nontoxic molecule predicted by a machine learning tool
Here we aim to test the notion that overcoming cancer cells’ acquired resistance to chemotherapy drugs may be achieved by administrating together with the main drug a molecule that is not toxic by itself but enhances the drug efficacy in killing the resistant cells. Finding such a supplementary mole...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071434 | Pride
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