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TranscriptomicsEpigenetic Reprogramming Modulates Malignant Properties of Human Liver Cancer Cells
Reversal of DNA hypermethylation and associated gene silencing is an emerging cancer therapy approach. In this context we have addressed the impact of epigenetic alterations and local microenvironment on the functional and transcriptional reprogramming of hepatic cancer stem cells. (CSCs) using t...
ORGANISM(S): Homo sapiens 
2014-05-26 | E-GEOD-47932 | biostudies-arrayexpress
TranscriptomicsDifferentiation stage-specific donor memory in induced pluripotent stem cells (iPSC) generated from hepatic lineage cells
Recent studies suggested that embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) may represent different pluripotent states as defined by gene expression profiles and differentiation potential. Here we addressed a contribution of a lineage stage-specific donor cell memory in mod...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-33110 | biostudies-arrayexpress
TranscriptomicsEpigenetic Based Enrichment of Cancer Stem Cells: Mechanistic and Clinical Implications for Liver Cancer
Global transcriptiome changes between SP and NSP cells of liver cancer cell lines w and w/o Zebularine treatment Huh7,WRL68, KMCH FACS sorted in SP and NSP w and w/o Zebularine and subjected to illumina microarray analysis.
ORGANISM(S): Homo sapiens 
2011-10-03 | E-GEOD-24520 | biostudies-arrayexpress
TranscriptomicsMolecular mechanisms of hepatocarcinogenesis in c-Myc/Tgfa transgenic mice
A complete understanding of molecular mechanisms that underlie cancer onset and progression could provide a basis to improve early diagnosis and more effective treatment. However, this is still a challenge in human, partly due to the difficulty of analyzing the early stages of the disease. In this c...
ORGANISM(S): Mus musculus 
2011-09-27 | E-GEOD-25587 | biostudies-arrayexpress
TranscriptomicsProliferation of mouse thyroid cells after partial thyroidectomy
While the thyroid has the capacity to grow in response to a stimulus that perturbs the pituitary-thyroid axis, cells involved in this process have not been well characterized. In this study, partial thyroidectomy was used to produce regeneration. Histological and gene profiling analyses were carri...
ORGANISM(S): Mus musculus 
2012-04-01 | E-GEOD-25934 | biostudies-arrayexpress
TranscriptomicsLoss of HGF/c-Met signaling in hepatocytes leads to disruption of the hepatic microenvironment and aggravates the progression of chronic liver fibrosis
Background: HGF/c-Met signaling plays a pivotal role in hepatocyte survival and tissue remodeling during liver regeneration. Treatment with HGF has been shown to accelerate resolution of fibrotic liver lesions in experimental animal models. To formally address the importance of c-Met signaling in he...
ORGANISM(S): Mus musculus 
2011-11-09 | E-GEOD-25583 | biostudies-arrayexpress
TranscriptomicsMicroRNA targetome analysis during HCMV infection
To elucidate miRNA-mediated temporal crosstalk during productive infection, we identified genome-wide miRNA target sites using Argonaute-crosslinking and immunoprecipitation followed by high-throughput sequencing (AGO-CLIPseq) in human cytomegalovirus (HCMV)-infected cells and evaluated the targetin...
ORGANISM(S): Homo sapiens 
2014-12-03 | E-GEOD-63797 | biostudies-arrayexpress
TranscriptomicsConditional elimination of c-Met signaling in the liver aggravates oxidative stress and cholestasis, and deregulates lipid metabolism, under a high cholesterol diet
Background: Genetic elimination of c-Met signaling in the liver has been shown to impact many cellular pathways involved in repair, regeneration, lipid homeostasis and redox balance. In this study, we analyzed a nutritional model of hepatic steatosis in Met fl/fl ; Alb-Cre +/- (MetKO) mice in a 129S...
ORGANISM(S): Mus musculus 
2012-07-10 | E-GEOD-30651 | biostudies-arrayexpress
TranscriptomicsCOP1 siRNA knockdown in human Hepatocellular carcinoma cells
Development of targeted therapeutics for hepatocellular carcinoma (HCC) remains a major challenge. We have previously demonstrated that constitutively photomorphogenic 1 (COP1), which regulates p53 activity by ubiquitination, is frequently overexpressed in human HCC. Here we examined whether molecul...
ORGANISM(S): Homo sapiens 
2010-11-01 | E-GEOD-21955 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of side population cells of mouse thyroid before and after partial thyroidectomy
Side population (SP) cells are enriched with genes involved in stem cell activity and/or lineage specifications. Stem cell marker genes are upregulated after partial thyroidectomy. Four-condition experiment: control side population (CSP) vs. control main population (CMP) vs. thyroidectomized side po...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-34513 | biostudies-arrayexpress
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