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MetabolomicsMetabolic Database of Sepsis
SepsisLiMetDB is a curated metabolomics database characterizing sepsis-induced liver injury, comprising 2,894 metabolites identified from 88 longitudinal clinical samples (20 healthy controls, 36 sepsis without liver injury, 32 sepsis with liver injury) across four disease progression timepoints (D1...
2026-08-03 | MTBLS14459 | MetaboLights
UnknownSepsis-induced endothelial dysfunction drives acute-on-chronic liver failure through Angiopoietin-2-HGF-C/EBPβ pathway.
Not available
S-EPMC10440279 | biostudies-literature
ProteomicsGlobal Lysine Acetylome Analysis of LPS-Stimulated HepG2 Cells Identifies Hyperacetylation of PKM2 as a Metabolic Reg-ulator in Sepsis
Sepsis-induced liver dysfunction is a frequent event and is strongly associated with mortality. Establishing a causative link between protein post-translational modification (PTM) and diseases is challenging. We studied the relationship among the lysine acetylation (Kac), the sirtuin (SIRTs), and th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-30 | PXD027496 | Pride
Sepsis-induced liver dysfunction  hyperacetylation  sirt  lysine acetylation  pyruvate kinase m2 
TranscriptomicsTranscriptional Profiling in Sepsis-induced Experimental Multiple Organ Dysfunction Syndrome
Sepsis-induced multiple organ dysfunction syndrome (MODS) is a major cause of morbidity and mortality in critically ill patients and remains impervious to most therapeutic interventions. We utilized a clinically relevant murine model of MODS induced by ventilator-associated pneumonia to systematical...
ORGANISM(S): Mus musculus 
2014-12-31 | GSE60088 | GEO
ProteomicsLiver proteomic reveals the key proteins involved in host immune response to sepsis
Sepsis is a serious infection-induced response in the host,which can lead to organ dysfunction. It is of great importance to unravel the relationship between sepsis and host immune response and its mechanisms of action. Liver is one of the most vulnerable organs in sepsis, however, the specific path...
ORGANISM(S): Rattus Norvegicus 
2022-11-15 | PXD037868 |
UnknownFC-99 ameliorates sepsis-induced liver dysfunction by modulating monocyte/macrophage differentiation via Let-7a related monocytes apoptosis.
Not available
S-EPMC5871089 | biostudies-literature
UnknownSimvastatin Prevents Liver Microthrombosis and Sepsis Induced Coagulopathy in a Rat Model of Endotoxemia.
Not available
S-EPMC8997834 | biostudies-literature
UnknownSepsis induced dysfunction of liver type 1 innate lymphoid cells.
Not available
S-EPMC11363412 | biostudies-literature
UnknownSingle-cell RNA sequencing reveals the effects of capsaicin in the treatment of sepsis-induced liver injury.
Not available
S-EPMC10556204 | biostudies-literature
ProteomicsHNF4α contributes to hepatic CAR dysfunction in polymicrobial sepsis
Constitutive androstane receptor (CAR) is a xenobiotic nuclear receptor mainly expressed in the liver, where it regulates drug metabolism and energy homeostasis. CAR has emerged as a promising therapeutic target for diabetes, fatty liver disease, and alcoholic liver disease, but it has not been inve...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD062961 | Pride
Lc-msms Clp-induced peritoneal sepsis Mouse Liver 
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