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Multiple myeloma (MM) is a common hematological malignancy with poorly understood recurrence and relapse mechanisms. Notably, bortezomib resistance leading to relapse makes MM treatment significantly challenging. To clarify the drug resistance mechanism, we employed a quantitative proteomics approac...
ORGANISM(S): Homo sapiens (Human) 
2021-03-03 | PXD022182 | Pride
This study investigates the proteomic alterations in pancreatic cancer cells resulting from Serpinb9 knockdown (KD) compared to normal control (NC). Two experimental groups, each consisting of three biological replicates, were analyzed to identify key proteins and pathways associated with Serpinb9's...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-01 | PXD059411 | Pride
After exposing a panel of non-small cell lung cancer (NSCLC) cell lines to cytotoxic CD8+ T-cells, we found SERPINB9 to be the most differentially expressed gene between the cell lines most and least resistant to T-cell killing.
ORGANISM(S): Homo sapiens 
2022-10-12 | GSE214992 | GEO
SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response
Dermatofibrosarcoma protuberans (DFSP) is a rare cutaneous soft tissue sarcoma which prone to high recurrence rate, especially the high grade sub-type. We applied label-free proteomics quantification to profile the molecular signatures of DFSP tumors in contrast to adjacent normal tissues.
ORGANISM(S): Homo sapiens (Human) 
2026-09-09 | PXD074336 | Pride
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