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UnknownLighting-Up the Far-Red Fluorescence of RNA-Selective Dyes by Switching from Ortho to Para Position.
Not available
S-EPMC10003335 | biostudies-literature
ProteomicsMembrane IL-18 Identifies a Unique Human Macrophage Subset with Distinct Phenotypic and Functional Properties
This study adds a tile to the macrophage heterogeneity in humans. We characterize a unique macrophage population expressing membrane-associated IL-18 (mIL-18) that shows peculiar proteomic, phenotypic, ultrastructural, and functional properties. mIL-18+ macrophages exhibit increased levels of key pr...
ORGANISM(S): Homo sapiens (Human) 
2025-11-17 | PXD058726 | Pride
Il-18 Macrophages Adult cancer patients  pediatric neuroblastoma Endocytosis Trem2 
UnknownRepurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer.
Not available
S-EPMC11334304 | biostudies-literature
GenomicsA sequence-based genetic dissection of human immune cell types and implications for immune-related disease.
The immune system is an intricate biological network mediating interactions with other organisms while preserving the integrity of our tissues. By mounting appropriate responses it protects us from a vast range of pathogens while inadvertent immune system attacks on self result in autoimmune disease...
EGAS00001000574 | EGA
UnknownMiR-182-3p targets TRF2 and impairs tumor growth of triple-negative breast cancer.
Not available
S-EPMC9832842 | biostudies-literature
UnknownAnnexin A8 deficiency delays atherosclerosis progression.
Not available
S-EPMC11748212 | biostudies-literature
TranscriptomicsSLAMF1/CD150 regulates chemotaxis, autophagy and therapy responses in chronic lymphocytic leukemia patients
This work shows that signaling-lymphocytic-activation-molecule-1 (SLAMF1), a co-stimulatory molecule and a microbial sensor, is expressed by normal CD19+/CD5+ B-lymphocytes. Its expression is lost in a subset of patients with chronic lymphocytic leukemia (CLL) characterized by an aggressive form of ...
ORGANISM(S): Homo sapiens 
2015-05-23 | E-GEOD-69165 | biostudies-arrayexpress
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo Sapiens 
2021-01-23 | PXD011261 | panorama
TranscriptomicsThe enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting
The ecto-enzyme CD38 is a marker of unfavorable prognosis for chronic lymphocytic leukemia (CLL) patients and an indicator of activation and proliferation of leukemic cells. Here we show that CD38 is enzymatically active in primary CLL cells and that its forced expression increases disease aggressiv...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-56369 | biostudies-arrayexpress
UnknownInteractions between BRD4S, LOXL2, and MED1 drive cell cycle transcription in triple-negative breast cancer
Not available
S-SCDT-10_15252-EMMM_202318459 | biostudies-other
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