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ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo Sapiens 
2021-01-23 | PXD011261 | panorama
ProteomicsMelanoma RBPome identification reveals PDIA6 as an unconventional RNA-binding protein involved in metastasis
RNA-binding proteins (RBPs) have been relatively overlooked in cancer research despite their contribution to virtually every cancer hallmark. Here, we use RNA interactome capture(RIC) to characterize the melanoma RBPome and uncover novel RBPs involved in melanoma progression. Comparison of RIC profi...
ORGANISM(S): Homo sapiens (Human) 
2022-07-19 | PXD029927 | Pride
Rbp Mass spectrometry Melanoma 
ProteomicsLow-density lipoprotein receptor-related protein 1 (LRP1)-derived peptides protect against aggregation of LDL and cholesterol loading of vascular cells. Molecular and Cellular basis for antiatherosclerotic efficacy
LRP1 and, in particular the region that spans the C-terminal half of domain CR9 (from Gly1127 to Cys1140), named LP3, is essential for aggregated LDL internalization and human coronary vascular smooth muscle cells (hcVSMC)-cholesterol loading. Here, we investigated whether LP3 and its retro-enantio ...
ORGANISM(S): Homo sapiens (Human) 
2019-06-26 | PXD011246 | Pride
Lrp1 Proteomics Ldl Atherosclerosis 
TranscriptomicsEffective sorafenib treatment response in a panel of genomically-characterized malignant peripheral nerve sheath tumor orthoxenograft models
Background: Malignant peripheral nerve sheath tumors (MPNST) are soft-tissue sarcomas that can arise either sporadically or in association with neurofibromatosis type 1 (NF1). These aggressive malignancies confer poor survival, with no effective therapy available. Methods: We generated five patient-...
ORGANISM(S): Homo sapiens 
2015-04-15 | E-GEOD-60082 | biostudies-arrayexpress
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