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MetabolomicsCycloleucine disturbs functions of porcine Sertoli cells via modulating gene expression and metabolism

Cycloleucine (CL) is a methyl donor inhibitor. Our previous findings showed that CL could affect meiotic maturation and developmental potency of porcine oocytes by reducing nucleic acid N6-methyladenosine (m6A) epigenetic modification level. However, the effects of CL on porcine male reproduction...

2025-09-13 | MTBLS12990 | MetaboLights
ProteomicsMultiomics Approach to Profiling Development of the Spermatogonial Stem Cell Niche Focused on Sertoli cell Maturation
Spermatogonial stem cells are the foundation of spermatogenesis and as such can serve as a tool for the treatment of infertility in prepubertal cancer survivors. Spermatogonial stem cells are unique as they develop from primordial germ cells (PGCs), which colonize the developing tubules as immature ...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2023-02-24 | PXD037764 | Pride
Metabolic microenvironment Niche development Lipid metabolism Sertoli cell maturation 
UnknownFBXO38 Ubiquitin Ligase Controls Sertoli Cell Maturation.
Not available
S-EPMC9234700 | biostudies-literature
TranscriptomicsTAp73 is essential for germ cell adhesion and maturation in testis
A core evolutionary function of the p53 family is to protect the genomic integrity of gametes. However, the role of p73 in the male germline is unknown. Here we uncover that TAp73 unexpectedly functions as adhesion and maturation factor of the seminiferous epithelium orchestrating spermiogenesis. TA...
ORGANISM(S): Mus musculus 
2014-03-07 | E-GEOD-52124 | biostudies-arrayexpress
ProteomicsPIK3C3/VPS34 controls Sertoli cell polarity in the mouse testis through the stabilization of the actin cytoskeleton
Sertoli cells are highly polarized testicular cells that provide a nurturing environment for germ cell development and maturation during spermatogenesis. The Class III PI3K, PIK3C3/VPS34 plays key roles in endosomal membrane traffic and macroautophagy in various cell types; however, its role in Sert...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD036242 | Pride
Sertoli cell Cell polarity Autophagy F-actin Spermatogenesis Pik3c3/vps34 
ProteomicsPIK3C3/VPS34 controls Sertoli cell polarity in the mouse testis through the stabilization of the actin cytoskeleton
Sertoli cells are highly polarized testicular cells that provide a nurturing environment for germ cell development and maturation during spermatogenesis. The Class III PI3K, PIK3C3/VPS34 plays key roles in endosomal membrane traffic and macroautophagy in various cell types; however, its role in Sert...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD036240 | Pride
Sertoli cell Cell polarity Autophagy F-actin Spermatogenesis Pik3c3/vps34 
TranscriptomicsTranscription profiling of rat seminiferous tubules, purifed germ cells and sertoli cells
Mammalian spermatogenesis is a complex biological process that occurs within a highly organized tissue, the seminiferous epithelium. The coordinated maturation of spermatogonia, spermatocytes and spermatids suggests the existence of precise programs of gene expression in these cells as well as in t...
ORGANISM(S): Rattus norvegicus 
2008-06-20 | E-GEOD-8978 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of testis from wild type mice and mice with a Sertoli-specific ablation of Dicer
Assess the transcriptomic effects of Sertoli-specific ablation of Dicer in mice
ORGANISM(S): Mus musculus 
2009-01-06 | E-TABM-426 | biostudies-arrayexpress
UnknownConnexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation.
Not available
S-EPMC9334284 | biostudies-literature
UnknownGenome-wide profiling of DNA 5-hydroxymethylcytosine during rat Sertoli cell maturation.
Not available
S-EPMC5423031 | biostudies-literature
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