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Polymorphonuclear leukocytes (PMNs) were obtained from healthy individuals (Healthy1, Healthy2, Healthy3, and Healthy4) or patients with X-linked chronic granulomatous disease (XCGD1, XCGD2, XCGD3, XCGD4, XCGD5, and XCGD6). The studies were performed in accordance with a protocol approved by the Ins...
ORGANISM(S): Homo sapiens 
Hyper IgE Recurrent Infection Syndrome (HIES or Job’s syndrome), is a rare disorder of immunity and connective tissue, typically manifest with boils, cyst-forming pneumonias, and extremely elevated serum IgE as well as retained primary dentition and bone abnormalities. Inheritance can be autosomal...
ORGANISM(S): Homo sapiens 
The goal is to discover novel circulating immune complexes (ICx) in the serum of Lupus Nephritis (LN) as potential biomarkers. Protein A/G magnetic beads or C1q-coated plates were used to capture ICx in the serum of LN, followed by the identification of immunoglobulin-binding proteins using liquid c...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD031069 | Pride
Identification of bacterial antigens within cecal bacterial lysate was performed by using serum antibodies from control and DC-LMP1/CD40 animals for immunoprecipitation followed by label-free liquid chromatography tandem mass spectrometry (LC-MS/MS). Serum antibodies were coupled to beads and incuba...
ORGANISM(S): Helicobacter hepaticus 
2021-02-25 | PXD018025 | Pride
This experiment investigated transcriptomic responses of mouse intestinal adenoma organoids to circulating factors induced by acute exercise. Intestinal adenoma organoids derived from an Lgr5-creER;Apcfl/fl mouse model were cultured with 1% human serum collected immediately before or after a maximal...
ORGANISM(S): Mus musculus 
This dataset of microarray analysis was designed to examine the impact of high glucose-culture on transcriptomics/gene expression in primary human CD8+ T cells. Primary human CD8+ T cells were isolated from peripheral blood mononulcear cells of healthy donors and stimulated with anti-CD3/anti-CD28 a...
ORGANISM(S): Homo sapiens 
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