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ProteomicsIPs of SETD1A COMPASS-HUMAN LC-MSMS
Mapping physical interactions of SETD1A COMPOASS in HEK293T cells using endogenous immunoprecipitation followed by label-free quantitative proteomics. We found a novel protein interacts with SETD1A, which is RAD18 (DNA damage repair protein).
ORGANISM(S): Homo sapiens (Human) 
2019-06-13 | PXD012549 | Pride
Lc-msms Human Setd1a compass 
GenomicsEpigenetic modification of GR enhancers by SETD1A/COMPASS complex in murine macrophages
Epigenetic modification of GR enhancers by SETD1A/COMPASS complex in murine macrophages
PRJNA564551 | ENA
GenomicsEpigenetic modification of GR enhancers by SETD1A/COMPASS complex in murine macrophages
Nuclear interaction studies by ChIP coupled with mass spectrometry identified the COMPASS/SETD1A complex as interaction partner of the glucocorticoid receptor (GR) in murine bone marrow-derived macrophages (BMDMs). Here, we profiled the occupancy of SETD1A and CXXC1, two subunits of the COMPASS/SETD...
ORGANISM(S): Mus musculus 
2020-12-31 | GSE136070 | GEO
GenomicsThe MLL3/MLL4 branch of the COMPASS family regulates H3K4 monomethylation at enhancers
Histone H3 lysine 4 (H3K4) can be mono-, di-, and trimethylated by members of the COMPASS (COMplex of Proteins ASsociated with Set1) family from yeast to human and these modifications can be found at distinct regions of the genome. Monomethylation of histone H3K4 (H3K4me1) is relatively more enriche...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-51176 | biostudies-arrayexpress
GenomicsContext Dependency of Set1/COMPASS Mediated H3 Lysine 4 Trimethylation
The stimulation of trimethylation of histone H3 lysine 4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied with multiple mechanisms proposed for this form of histone crosstalk. Cps35/Swd2 within COMPASS is considered to bridge these processes. However, a truncated form of Set1 (762-Se...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-09 | E-GEOD-53241 | biostudies-arrayexpress
UnknownThe glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
Not available
S-EPMC7873837 | biostudies-literature
GenomicsTET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS
TET proteins convert 5-methylcytosine to 5-hydroxymethylcytosine, an emerging dynamic epigenetic state of DNA that can influence transcription. Evidence has linked TET1 function to epigenetic repression complexes, yet mechanistic information, especially for the TET2 and TET3 proteins, remains limite...
ORGANISM(S): Mus musculus 
2013-02-07 | E-GEOD-36620 | biostudies-arrayexpress
GenomicsH3K4methylation in Setd1a loss-of-function Raw264.7 cells upon LPS or Dex+LPS stimulation
Nuclear interaction studies by ChIP coupled with mass spectrometry identified the COMPASS/SETD1A complex as interaction partner of the glucocorticoid receptor (GR) in murine bone marrow-derived macrophages (BMDMs). Here, we profiled H3K4me1, H3K4me2 and H3K4me3 in wild-type and Setd1a hypermorphic (...
ORGANISM(S): Mus musculus 
2020-12-31 | GSE138017 | GEO
UnknownThe COMPASS complex maintains the metastatic capacity imparted by a subpopulation of cells in UPS.
Not available
S-EPMC11233968 | biostudies-literature
GenomicsSETD1A protects from senescence through regulation of the mitotic gene expression program
SETD1A, a member of the Set1/COMPASS family maintaining H3K4 methylation in the promoters of transcriptionally active genes, is critical for the execution of developmental gene expression and is overexpressed in multiple cancers including breast cancer1-3. Here we show that SETD1A is essential for s...
ORGANISM(S): Homo sapiens 
2019-07-08 | GSE117427 | GEO
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