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ProteomicsLaser microdissection and mass spectrometry shows loss of podocyte proteins in minimal change disease and focal segmental glomerulosclerosis.
Minimal change disease and primary focal segmental glomerulosclerosis (FSGS) are common causes of nephrotic syndrome. Both diseases present with massive proteinuria and widespread foot process effacement on electron microscopy examination. On the other hand, secondary FSGS can also present with sign...
ORGANISM(S): Homo sapiens (Human) 
2025-12-29 | PXD057165 | Pride
Laser microdissection Focal segmental glomerulosclerosis Mass spectrometry Minimal change disease 
ProteomicsApolipoprotein E is associated with dense deposits in dense deposit disease
C3 glomerulopathy (C3G) is a rare disease resulting from dysregulation of the alternative pathway (AP) of complement. C3G includes C3 glomerulonephritis (C3GN) and dense deposit disease (DDD). Both C3GN and DDD are characterized by bright glomerular C3 staining on immunofluorescence studies. However...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD045319 | Pride
Human Tandem mass spectrometry Kidney Lcm Glomeruli 
ProteomicsFat1 is atarget antigen in de novo allograft membranous nephropoathy associated with antibody mediated rejection.
Membranous nephropathy (MN) occurs either as recurrent or de novo MN in the kidney allograft. Recurrent MN is most often associated with antibodies to the target antigen M-type phospholipase A2 receptor (PLA2R). 1-3 Most cases of de novo MN are PLA2R-negative and the target antigen in unknown.2 We h...
ORGANISM(S): Homo sapiens (Human) 
2024-10-22 | PXD055559 | Pride
Kidney transplant. Fat1 De novo membranous nephropathy 
UnknownQuantifying the fatal and non-fatal burden of disease associated with child growth failure, 2000-2023: a systematic analysis from the Global Burden of Disease Study 2023.
Not available
S-EPMC12674951 | biostudies-literature
UnknownGlobal, regional, and national incidence of six major immune-mediated inflammatory diseases: findings from the global burden of disease study 2019.
Not available
S-EPMC10507198 | biostudies-literature
UnknownGlobal, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC10364581 | biostudies-literature
UnknownGlobal, regional, and national burden of HIV/AIDS, 1990-2021, and forecasts to 2050, for 204 countries and territories: the Global Burden of Disease Study 2021.
Not available
S-EPMC11612058 | biostudies-literature
UnknownGlobal Burden of Cardiovascular Diseases and Risks, 1990-2022.
Not available
S-EPMC7615984 | biostudies-literature
UnknownGlobal, regional, and national burden of disorders affecting the nervous system, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC10949203 | biostudies-literature
UnknownGlobal burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021.
Not available
S-EPMC11120204 | biostudies-literature
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