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TranscriptomicsGenome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue
Background Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. Methodology/Principal Findin...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-17924 | biostudies-arrayexpress
ProteomicsEarly NK-cell and T-cell dysfunction marks progression to severe dengue in patients with obesity and healthy weight
Dengue is a mosquito-borne virus infection affecting half of the world’s population for which therapies are lacking. The role of T and NK-cells in protection/immunopathogenesis remains unclear for dengue for dengue. We performed a longitudinal phenotypic, functional and transcriptional analyses of T...
ORGANISM(S): Homo sapiens (Human) 
2025-05-21 | PXD061694 | Pride
Dengue Cd4+ t-cells Cd8+ t-cells Co-inhibitory receptors Cytotoxic cells Severe dengue biomarkers Nk-cells Type-i ifn 
GenomicsUnraveling potential gene biomarkers for dengue infection through RNA sequencing
Unraveling potential gene biomarkers for dengue infection through RNA sequencing
PRJNA1171376 | ENA
GenomicsDiscovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
Discovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
PRJNA788392 | ENA
GenomicsDiscovery and validation of circulating miRNAs for the clinical prognosis of severe dengue
Background: dengue is a potentially life-threatening viral infection. Early prognostic markers of severe complications may improve case management and reduce dengue-related mortalities. This study aimed to identify circulating microRNAs (miRNAs) as biomarkers for predicting severe dengue. Methods: S...
ORGANISM(S): Homo sapiens 
2022-10-26 | GSE190749 | GEO
TranscriptomicsTime since Onset of Disease and Individual Clinical Markers Associate with Transcriptional Changes in Uncomplicated Dengue
Background Dengue virus (DENV) infection causes viral haemorrhagic fever that is characterized by extensive activation of the immune system. The aim of this study is to investigate the kinetics of the transcriptome signature changes during the course of disease and the association of genes in these ...
ORGANISM(S): Homo sapiens 
2015-02-28 | E-MTAB-3162 | biostudies-arrayexpress
TranscriptomicsUnraveling potential gene biomarkers for dengue infection through RNA sequencing
This pilot study, aimed to profile the host transcriptome as a potential strategy for identifying specific biomarkers for dengue prediction and detection. High-throughput RNA-sequencing (RNA-seq) was employed to generate host transcriptome profiles in 16 dengue patients and 10 healthy controls. Diff...
ORGANISM(S): Homo sapiens 
2024-10-10 | GSE279208 | GEO
UnknownMeta-analysis of biomarkers for severe dengue infections.
Not available
S-EPMC5602679 | biostudies-literature
UnknownSerum biomarkers and anti-flavivirus antibodies at presentation as indicators of severe dengue.
Not available
S-EPMC9997924 | biostudies-literature
UnknownA Proteomic Approach Identifies Candidate Early Biomarkers to Predict Severe Dengue in Children.
Not available
S-EPMC4764501 | biostudies-literature
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