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MetabolomicsKynurenic acid underlies sex-specific immune responses to COVID-19
Sex-related differences in Coronavirus Disease (COVID-19) severity and mortality exist, with the male sex being a potential risk factor1. It was recently shown that patients with mild to moderate SARS-CoV-2 infection have elevated levels of inflammatory cytokines and chemokines, and sex-differences ...
2020-09-08 | MTBLS1987 | MetaboLights
MetabolomicsHaplotype-resolved female and male genomes reveal sex-specific genomic regions and provide insights into thermal stress in Scapharca subcrenata

Integrated analyses of transcriptomic, proteomic and metabolomic data sets consistently highlights the crucial involvement of protein function and retinol metabolism pathways in the heat-resistant strain of S. subcrenata. These findings underscore the significance of these pathways in e...

2024-11-11 | MTBLS11038 | MetaboLights
GenomicsUnbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and diseas...
ORGANISM(S): Mus musculus 
2010-09-28 | E-GEOD-21777 | biostudies-arrayexpress
TranscriptomicsWidespread Generation of Alternative UTRs Contributes to Sex-specific RNA Binding by UNR
Upstream of N-ras (UNR) is a conserved RNA-binding protein that regulates mRNA translation and stability by binding to sites generally located in untranslated regions (UTRs). In Drosophila, sex-specific binding of UNR to msl2 mRNA and the non-coding RNA roX plays key roles in the control of X-chromo...
ORGANISM(S): Drosophila melanogaster 
2011-10-25 | E-GEOD-33178 | biostudies-arrayexpress
TranscriptomicsSex-specific early growth hormone response genes in rat liver (Rattus norvegicus)
A series of two color gene expression profiles obtained using Agilent 44K expression microarrays was used to examine sex-dependent and growth hormone-dependent differences in gene expression in rat liver. This series is comprised of pools of RNA prepared from untreated male and female rat liver, hy...
ORGANISM(S): Rattus norvegicus 
2008-05-24 | E-GEOD-11529 | biostudies-arrayexpress
ProteomicsAnalysis of 5000 year-old human teeth using optimized large-scale and targeted proteomics approaches for detection of sex-specific peptides
Tooth is a remarkable source of information for paleoanthropologists. Investigation of ancient dental proteomes is able to provide biomolecular data helping at understanding past life. In particular, the enamel protein amelogenin (AMEL) offers the possibility to determine the sex of the specimen. He...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD014442 | Pride
Sex determination Amelogenin Data dependent acquisition Tooth Paleoproteomics Parallel reaction monitoring 
ProteomicsSex-specific social behavior and amygdala proteomic deficits in Foxp2+/- mutant mice
In humans, mutations in the transcription factor encoding gene, FOXP2, are associated with language and Autism Spectrum (ASD) Disorders, the latter characterized by deficits in social interactions. However, little is known regarding the function of Foxp2 in male or female social behavior. Our previo...
ORGANISM(S): Mus musculus (Mouse) 
2021-07-07 | PXD026978 | Pride
Aggression Proteomics Sex-specific differences Medial amygdala (mea) Social behavior Foxp2 
TranscriptomicsAn SRY homolog cooperates with a transposon-derived CENP-B protein to control sex-specific directed recombination
Occupancy profiling of Myc tagged Mc protein in fission yeast. Agilent 60mer array was used to analyze DNA recovered by immunoprecipitation of Mc-myc protein from culture of fission yeast.
ORGANISM(S): Schizosaccharomyces pombe 
2011-11-21 | E-GEOD-32996 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chicken 18 day embryonic chicken heart, brain, and gonad to determine sex specific gene expression
The contrasting dose of sex chromosomes in males and females potentially introduces a large-scale imbalance in levels of gene expression between sexes. In many organisms dosage compensation has thus evolved to equalize sex-linked gene expression in males and females1,2, in mammals achieved by X chro...
ORGANISM(S): Gallus gallus 
2008-11-06 | E-GEOD-8693 | biostudies-arrayexpress
TranscriptomicsIntegrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilisation in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here we report the first transcr...
ORGANISM(S): Plasmodium falciparum 
2016-06-28 | E-GEOD-75795 | biostudies-arrayexpress
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