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ProteomicsAllele-Specific Protein Abundance in Human Brain
We describe a method for identifying peptides that result from missense changes and identify peptides among 2 human brains that would have otherwise not been detected. Next, we use this data to estimate of allele-specific protein abundance in human brain for an average per individual, and to estimat...
ORGANISM(S): Homo sapiens (Human) 
2017-07-31 | PXD004143 | Pride
Proteogenomics genomics variants proteomics 
ProteomicsA U1-70K Protein Interaction Network Reveals a Functional Class of RNA Binding Proteins with Mixed Charge Domains
U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and other proteins of the spliceosome complex are mislocalized to cytoplasmic aggregates in Alzheimer’s disease (AD) brain, yet understanding of the specific mechanisms that cause their aggregation is limited. Many of the RNA binding proteins (RBPs)...
ORGANISM(S): Homo sapiens (Human) 
2018-06-21 | PXD008260 | Pride
U1-70k 
UnknownDeep high-temperature hydrothermal circulation in a detachment faulting system on the ultra-slow spreading ridge.
Not available
S-EPMC7064610 | biostudies-literature
ProteomicsEngineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin
The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson’s disease. An essential role of Parkin is to initiate mitophagy by ubiquitinating mito...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD063080 | Pride
Ubiquitin Parkin Mass spectrometry E3 
UnknownProximity Labeling Proteomics Reveals Kv1.3 Potassium Channel Immune Interactors in Microglia.
Not available
S-EPMC11780389 | biostudies-literature
UnknownMetabolic phenotype-microRNA data fusion analysis of the systemic consequences of Roux-en-Y gastric bypass surgery.
Not available
S-EPMC4766927 | biostudies-literature
UnknownBmp signaling exerts opposite effects on cardiac differentiation.
Not available
S-EPMC4924880 | biostudies-literature
ProteomicsMolecular signatures of neuroinflammation induced by α-synuclein aggregates-A multi-proteomics approach (Mouse Arm)
Alpha-synuclein aggregates (αSynAgg) are pathological hallmarks of Parkinson’s disease (PD) that induce microglial activation and immune-mediated neurotoxicity, although the molecular mechanisms of αSynAgg-induced immune activation are poorly defined. We used mass spectrometry to define proteomic ch...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-24 | PXD013691 | Pride
Snca Mouse Microglia Alpha synuclein aggregates Parkinsons disease 
UnknownTDP-43 toxic gain of function links ALS, FTD and Alzheimer's Disease through splicing dysregulation.
Not available
S-EPMC12247699 | biostudies-literature
ProteomicsBroad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy
Tauopathies are a group of more than twenty known disorders that involve progressive neurodegeneration, cognitive decline, and pathological tau accumulation. Current therapeutic strategies provide only limited, late-stage symptomatic treatment. This is partly due to lack of understanding of the mole...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD023562 | Pride
Mouse lc-ms/ms 
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