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TranscriptomicsiCLIP and NGS to map protein-RNA interactions for U1-snRNP proteins in Trypanosoma brucei
Individual-nucleotide resolution UV-crosslinking and immunoprecipitation (iCLIP) combined with high-throughput sequencing was performed to generate genome-wide binding maps of two U1-snRNP proteins: U1C and U1-70K in Trypanosoma brucei. 3 (2) biological replicates of U1C (U1-70K) -specific co-immuno...
ORGANISM(S): Trypanosoma brucei 
2014-05-16 | E-GEOD-43848 | biostudies-arrayexpress
ProteomicsA U1-70K Protein Interaction Network Reveals a Functional Class of RNA Binding Proteins with Mixed Charge Domains
U1 small nuclear ribonucleoprotein 70 kDa (U1-70K) and other proteins of the spliceosome complex are mislocalized to cytoplasmic aggregates in Alzheimer’s disease (AD) brain, yet understanding of the specific mechanisms that cause their aggregation is limited. Many of the RNA binding proteins (RBPs)...
ORGANISM(S): Homo sapiens (Human) 
2018-06-21 | PXD008260 | Pride
U1-70k 
ProteomicsU1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast
Transcription and splicing are coupled both temporally and physically. A previous cryo-EM structure of the human U1 snRNP and RNA polymerase pol II complex has shown that U1 snRNP uses predominantly the RRM domain of U1-70K to directly interact with the RPB2 subunit of pol II. However, residues on U...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-05-20 | PXD078573 | Pride
Yeast Spliceosome Splicing Pol ii Snrnp Prp40 
UnknownA novel intra-U1 snRNP cross-regulation mechanism: alternative splicing switch links U1C and U1-70K expression.
Not available
S-EPMC3798272 | biostudies-literature
UnknownCLK1 reorganizes the splicing factor U1-70K for early spliceosomal protein assembly.
Not available
S-EPMC8040622 | biostudies-literature
UnknownPhylogenetic comparison and splice site conservation of eukaryotic U1 snRNP-specific U1-70K gene family.
Not available
S-EPMC8211703 | biostudies-literature
UnknownU1 snRNP and RNA polymerase II interaction is predominantly mediated by Prp40 rather than U1-70K in yeast.
Not available
S-EPMC12407893 | biostudies-literature
UnknownMapping epitopes of U1-70K autoantibodies at single-amino acid resolution.
Not available
S-EPMC4815922 | biostudies-literature
UnknownThe U1-70K and SRSF1 interaction is modulated by phosphorylation during the early stages of spliceosome assembly.
Not available
S-EPMC11255866 | biostudies-literature
UnknownIsoforms of U1-70k control subunit dynamics in the human spliceosomal U1 snRNP.
Not available
S-EPMC2747018 | biostudies-literature
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