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UnknownSystematic review and meta-analysis of prognostic models in Southeast Asian populations with acute myocardial infarction.

Background

The cultural and genetic diversity of the Southeast Asian population has contributed to distinct cardiovascular disease risks, incidence, and prognosis compared to the Western population, thereby raising concerns about the accuracy of predicted risks of existing prognostic models....
S-EPMC9360484 | biostudies-literature
UnknownIdentification of Haptoglobin as a Potential Biomarker in Young Adults with Acute Myocardial Infarction by Proteomic Analysis.

Background

Acute myocardial infarction (AMI) molecular research in young adults is still limited. The aim of this study is to identify AMI proteomic biomarker(s) in young adults.

Methods

This study comprised of two phases namely discovery and verification. In the discovery phase, prot...
S-EPMC7409576 | biostudies-literature
UnknownThe impact of COVID-19 on clinical outcomes among acute myocardial infarction patients undergoing early invasive treatment strategy.

Background

The implications of coronavirus disease 2019 (COVID-19) infection on outcomes after invasive therapeutic strategies among patients presenting with acute myocardial infarction (AMI) are not well studied.

Hypothesis

To assess the outcomes of COVID-19 patients presenting with ...
S-EPMC9538930 | biostudies-literature
UnknownColchicine and cardiovascular outcomes in MINOCA: A retrospective cohort study.

Background

MINOCA accounts for 5 %-15 % of myocardial infarctions and is defined by <50 % coronary stenosis without an alternative diagnosis, with heterogeneous mechanisms that complicate care. Given the role of inflammation and microvascular dysfunction, we evaluated whether colchicine impr...
S-EPMC12554186 | biostudies-literature
UnknownRationale and design of the Virginia Commonwealth University-Anakinra Remodeling Trial-3 (VCU-ART3): A randomized, placebo-controlled, double-blinded, multicenter study.
There is clear association between the intensity of the acute inflammatory response during acute myocardial infarction (AMI) and adverse prognosis after AMI. Interleukin-1 (IL-1) is a pro-inflammatory cytokine released during AMI and involved in adverse remodeling and heart failure (HF). We describe...
S-EPMC6153042 | biostudies-literature
UnknownGuideline-directed medical therapy implementation during hospitalization for cardiogenic shock.

Aims

Despite significant morbidity and mortality, recent advances in cardiogenic shock (CS) management have been associated with increased survival. However, little is known regarding the management of patients who survive CS with heart failure (HF) with reduced left ventricular ejection fra...
S-EPMC11769606 | biostudies-literature
UnknownAdvancing acute MI care in densely populated low- and middle-income countries (LMICs): innovative stand-alone chest pain units for expedited triage and timely management.

Background

The incidence of myocardial infarction (MI) and its adverse effects on health and mortality remain high in densely populated low- and middle-income countries (LMICs). To address the issue of densely populated areas and timely access to primary PCI, chest pain units (CPUs) were dep...
S-EPMC11474207 | biostudies-literature
TranscriptomicsGene Expression profiles of colon from VhlF/F, VhlΔIE, VhlF/F/Apcmin/+, VhlΔIE/Apcmin/+
To identify the precise molecular mechanisms that could contribute to the increase in colon carcinogenesis, microarray gene expression analysis was performed on colon RNA isolated from 5-week-old VhlF/F and VhlΔIE, VhlΔIE/Apcmin/+ and VhlF/F/Apcmin/+ mice. Hypoxia-inducible factor (HIF) is a key mod...
ORGANISM(S): Mus musculus 
2012-03-07 | E-GEOD-36091 | biostudies-arrayexpress
TranscriptomicsGene Expression profiles of colon from Hif-1α+/+, Hif-1αLSL/LSL
To investigate the detailed molecular mechanisms for the regulatory role of HIF-1α in colon, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-1α+/+, Hif-1αLSL/LSL mice. Background & Aims: The progression and growth of solid tumors leads to a state wh...
ORGANISM(S): Mus musculus 
2014-05-14 | E-GEOD-55915 | biostudies-arrayexpress
TranscriptomicsGene Expression profiles of colon from Hif-2αF/F, Hif-2αlΔIE treated with DSS
To investigate the detailed molecular mechanisms for the regulatory role of HIF-2α in experimental colitis, microarray gene expression analysis was performed on colon RNA isolated from 6- to 8-week-old Hif-2αF/F, Hif-2αlΔIE mice treated with 3%DSS for 3 days. Background & Aims: Hypoxic inflammation ...
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-43416 | biostudies-arrayexpress
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