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Metabolomicsβ-Hydroxybutyrate Restores Social Deficits via Suppressing HDAC9 in the Anterior Cingulate Cortex of Shank3B-Deficient Mice

Autism spectrum disorder (ASD) is characterized by core deficits in social behavior, yet effective interventions remain limited. Ketogenic diet (KD) shows behavioral benefits in ASD, but the underlying mechanisms remain unclear. Here, using Shank3B knockout (KO) mice, we find that KD induces syst...

2026-07-08 | MTBLS14381 | MetaboLights
ProteomicsASO-treated Shank3 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061261 | Pride
Slc6a20a Aso Shank3 ko 
ProteomicsASO-treated Shank3 HT mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061258 | Pride
Aso Shank3 Slc6a20a 
ProteomicsASO-treated Shank3 HT mice proteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061255 | Pride
Shank3 ht Slc6a20a Aso 
UnknownJuvenile Shank3 KO mice adopt distinct hunting strategies during prey capture learning.
Not available
S-EPMC9768843 | biostudies-literature
UnknownDeciphering the Role of Shank3 in Dendritic Morphology and Synaptic Function Across Postnatal Developmental Stages in the Shank3B KO Mouse.
Not available
S-EPMC11978597 | biostudies-literature
UnknownEnhanced Glutamatergic Currents at Birth in Shank3 KO Mice.
Not available
S-EPMC6636579 | biostudies-literature
ProteomicsEndothelial SHANK3 Regulates Tight Junctions in the Neonatal Blood-Brain Barrier through β-Catenin Signaling
Autism spectrum disorder (ASD) is a neurodevelopmental condition caused by a combination of genetic and environmental factors. The blood-brain barrier (BBB) plays a key role in regulating environmental influences on the brain, yet its contributions to ASD remain unclear. We report that endothelium-s...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-07 | PXD059466 | Pride
Bend3. cells Shank3 Bioid2 Lc-ms/ms 
ProteomicsThe neomycin resistance cassette in the targeted allele of Shank3B knock-out mice has potential off-target effects to produce an unusual Shank3 isoform
Variants of the SH3 and multiple ankyrin repeat domains 3 (SHANK3), which encodes postsynaptic scaffolds, are associated with brain disorders. The targeted alleles in a few Shank3 knock-out (KO) lines contain a neomycin resistance (Neo) cassette, which may perturb the normal expression of neighborin...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-11-30 | MSV000086539 | MassIVE
ProteomicsASO treated adult Shank2 KO mice phosphoproteome
Decreased NMDA receptor function is a central mechanism implicated in various brain disorders, and extensive efforts to modulate NMDAR activity have been devoted in various therapeutic settings. We have previously established Slc6a20a as a novel glycine transporter, and using an antisense oligonucle...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-24 | PXD061254 | Pride
Slc6a20a Aso Shank2 ko 
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