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ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
MetabolomicsThe Relative Content and Distribution of Absorbed Volatile Organic Compounds in Rats Administered Asari Radix et Rhizoma Are Different between Powder- and Decoction-Treated Groups
Asari Radix et Rhizoma (ARR) is an important traditional Chinese medicine. Volatile organic compounds (VOCs) are the main active constituents of ARR. Research on the metabolite profile of VOCs and the difference of absorbed constituents in vivo after an administration of ARR decoction and powder wil...
2021-02-01 | MTBLS2053 | MetaboLights
UnknownLncRNA ZFAS1 as a SERCA2a Inhibitor to Cause Intracellular Ca2+ Overload and Contractile Dysfunction in a Mouse Model of Myocardial Infarction.
Not available
S-EPMC5959220 | biostudies-literature
UnknownFDFT1 maintains glioblastoma stem cells through activation of the Akt pathway.
Not available
S-EPMC11662426 | biostudies-literature
UnknownA Monte Carlo method for variance estimation for estimators based on induced smoothing.
Not available
S-EPMC4288129 | biostudies-literature
UnknownGenomic characterization and pathogenicity analysis of a porcine deltacoronavirus strain isolated in western China.
Not available
S-EPMC9419129 | biostudies-literature
UnknownEfficacy of Pulsatilla saponin B4 for treatment dairy cows affected with clinical mastitis.
Not available
S-EPMC12404452 | biostudies-literature
UnknownDeveloping an interpretable machine learning predictive model of chronic obstructive pulmonary disease by serum PFAS concentration.
Not available
S-EPMC12287074 | biostudies-literature
UnknownMultitarget Effects of Danqi Pill on Global Gene Expression Changes in Myocardial Ischemia.
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S-EPMC5816862 | biostudies-literature
UnknownUnfolding the A2 domain of von Willebrand factor with the optical trap.
Not available
S-EPMC2856187 | biostudies-literature
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