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ProteomicsQualitative and label-free quantitative analysis of protein changes in the lymphatic muscle cells isolated in a hind-limb lymphatic injury model in the sheep
We developed a large animal model, with clinically relevant gravitational loading on the lymphatic vasculature, that enables longitudinal tracking of lymphatic function in vivo as well as end-point analysis of vessel function and mechanics. One of two parallel lymphatic vessels in the sheep hind lim...
ORGANISM(S): Ovis aries 
2021-01-12 | PXD014343 | Pride
Sheep lymphatic muscle cells 
TranscriptomicsSingle epicardial cell transcriptome sequencing identifies Caveolin-1 as an essential factor in zebrafish heart regeneration
By contrast with mammals, adult zebrafish have a high capacity to regenerate damaged or lost myocardium through proliferation of spared cardiomyocytes. The epicardial sheet covering the heart is activated by injury and aids muscle regeneration through paracrine effects and as a multipotent cell sou...
ORGANISM(S): Danio rerio 
2015-12-15 | E-GEOD-75583 | biostudies-arrayexpress
UnknownIn vitro model reveals a role for mechanical stretch in the remodeling response of lymphatic muscle cells.
Not available
S-EPMC6335159 | biostudies-literature
TranscriptomicsDevelopment of gene expression profiles for murine breast tumours treated with Sunitinib
In order to establish a profile of gene expression of tumours treated with sunitinib, 4T1 breast tumours were allowed to establish in Balb/C mice for 1 week. The mice were then treated with 40 mg/kg Sunitinib in PBS and 3.72% DMSO (treatemt group) or PBS-DMSO vehicle alone (no treatment group), dail...
ORGANISM(S): Mus musculus 
2016-07-06 | E-GEOD-84048 | biostudies-arrayexpress
TranscriptomicsExtrauterine growth restriction on pulmonary vascular endothelial dysfunction in adult male rats: the role of epigenetic mechanisms
Early postnatal life is considered as a critical time window for determination of long-term metabolic states and organ functions. Extrauterine growth restriction (EUGR) causes the development of adult onset chronic diseases, including pulmonary arterial hypertension (PAH). However, the effects of nu...
ORGANISM(S): Rattus norvegicus 
2013-07-10 | E-GEOD-48648 | biostudies-arrayexpress
GenomicsGenetic Framework for GATA Factor Function in Vascular Biology
Vascular endothelial dysfunction underlies the genesis and progression of numerous diseases. Whereas the GATA transcription factor GATA-2 is expressed in endothelial cells and is implicated in coronary heart disease, it has been studied predominantly as a master regulator of hematopoiesis. As many q...
ORGANISM(S): Homo sapiens 
2011-08-11 | E-GEOD-29531 | biostudies-arrayexpress
TranscriptomicsLoss of apelin blocks the emergence of sprouting angiogenesis in experimental tumors
Angiogenesis-inhibitor (AI) drugs targeting vascular endothelial growth factor (VEGF) signalling to the endothelial cell (EC) are used to treat various cancers types. However, primary or secondary resistance to therapy is common. Clinical and pre-clinical studies suggest that other alternative pro-a...
ORGANISM(S): Mus musculus 
2023-04-06 | E-MTAB-11663 | biostudies-arrayexpress
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