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ProteomicsA CPC-shelterin-BTR axis regulates mitotic telomere deprotection
Telomeres prevent ATM activation by sequestering chromosome termini within telomere loops (t-loops). Mitotic arrest promotes telomere linearity and a localized ATM-dependent telomere DNA damage response (DDR) through an unknown mechanism. Using unbiased interactomics, biochemical screening, molecula...
ORGANISM(S): Homo sapiens (Human) 
2025-01-28 | PXD043281 | Pride
Mitotic deprotection  cpc  shelterin  btr complex 
ProteomicsIdentification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1
Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we rep...
ORGANISM(S): Homo sapiens (Human) 
2019-07-19 | PXD011356 | Pride
Trf2 Shelterin Dj1 Pgk1 Telomere Stress 
UnknownShelterin is a dimeric complex with extensive structural heterogeneity.
Not available
S-EPMC9351484 | biostudies-literature
GenomicsThe human TTAGGG Repeat Factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms of chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind ...
ORGANISM(S): Homo sapiens 
2011-05-03 | E-GEOD-26005 | biostudies-arrayexpress
UnknownProtection of the Telomeric Junction by the Shelterin Complex.
Not available
S-EPMC11370466 | biostudies-literature
UnknownProtection of the Telomeric Junction by the Shelterin Complex.
Not available
S-EPMC11404488 | biostudies-literature
GenomicsUbiquitin C-terminal hydrolase isozyme L1 (UCHL1) is associated with shelterin complex at interstitial telomeric sites
Ubiquitin C-terminal hydrolase isozyme L1 (UCHL1) is primarily expressed in neuronal cells and neuroendocrine cells. It is a multifunctional protein involved in deubiquitination, ubiquitination, and ubiquitin homeostasis. UCHL1 has been associated with various diseases, including many cancers, but i...
ORGANISM(S): Homo sapiens 
2018-02-23 | GSE97111 | GEO
UnknownTargeting the telomere and shelterin complex for cancer therapy: current views and future perspectives.
Not available
S-EPMC3822786 | biostudies-literature
UnknownSpatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.
Not available
S-EPMC5610946 | biostudies-literature
UnknownMultifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition.
Not available
S-EPMC8305809 | biostudies-literature
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