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PINA is a novel ATPase and DNA helicase highly conserved in archaea, the third domain of life. The PINA from Sulfolobus islandicus (SisPINA) forms a hexameric ring, promotes Holliday junction (HJ) migration, and physically and functionally interacts with Hjc, the HJ specific endonuclease. Here, we s...
ORGANISM(S): Sulfolobus islandicus REY15A 
2018-10-22 | PXD008644 | Pride
Tubular injury and peripheral fibroblast activation are the hallmarks of chronic kidney disease (CKD) and renal fibrosis, suggesting intimate communication between the two diseases. However, the underlying mechanisms remain to be determined. Exosomes play a role in shuttling proteins and other mater...
ORGANISM(S): Homo sapiens (Human) 
2022-05-20 | PXD030696 | Pride
The period from birth to two years is the phase of the fastest growth and development in children, as well as an important window for the development of intestinal microbiota. Dysbiosis of the gut microbiome can lead to various adverse conditions in children, including malabsorption and immune abnor...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD064558 | Pride
Label-free quantitative proteomic analysis for clinical tissues of 5 normal and 5 inflamed colonic mucosa. The EASY-nLC 1200 system and Q Exactive Plus were used for peptides detection. A total of 4102 proteins were identified, and 2713 proteins were quantified. According to the criterion fold chang...
ORGANISM(S): Homo Sapiens 
2025-03-12 | PXD061745 |
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