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ProteomicsEvolutionary collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
The rise of antibiotic resistance and decline of antibiotic discovery urgently calls for novel mechanistic understanding of pharmacological and evolutionary interactions between antibiotics and multidrug resistant bacteria to revitalize existing antibiotics. The evolutionary cross-resistance to anti...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2022-05-20 | PXD030906 | Pride
Collateral sensitivity，vancomycin-resistant enterococcus faecium，pleuromutilin 
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and Represents a Therapeutic Vulnerability in Hepatocellular Carcinoma
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Here, we found that R236 methylation of PHGDH promotes its activity and stimulates serine synthesis in hepatocellular carcinoma.
ORGANISM(S): Homo Sapiens 
2022-07-28 | PXD035061 |
ProteomicsPHGDH Arginine Methylation by PRMT1 Promotes Serine Synthesis and HCC Growth
Serine synthesis is crucial for tumor growth and survival, but its regulatory mechanism in cancer remains elusive. Phosphoglycerate dehydrogenase (PHGDH) is the first rate-limiting enzyme in serine biosynthesis pathway. Here, we analyzed immunoprecipitated PHGDH from human HEK293T cells by liquid ch...
ORGANISM(S): Homo Sapiens 
2022-07-29 | PXD035287 |
UnknownA chromosome-level genome assembly for Erianthus fulvus provides insights into its biofuel potential and facilitates breeding for improvement of sugarcane.
Not available
S-EPMC10363513 | biostudies-literature
ProteomicsProteome data from an external validation cohort using MRM-MS targeted proteomics assay
These are raw mass spectrometry files obtained by MRM from the external validation cohort, used to validate findings from the Guangzhou Nutrition and Health Study.
ORGANISM(S): Homo Sapiens 
2024-10-18 | PXD056935 |
UnknownTongxinluo and Functional Outcomes Among Patients With Acute Ischemic Stroke: A Randomized Clinical Trial.
Not available
S-EPMC11428006 | biostudies-literature
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