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MetabolomicsTranscriptomic and metabolomic analyses reveal the differential accumulation of phenylpropanoids and terpenoids in hemp autotetraploid and its diploid progenitor

Background

Cannabis sativa, a dioecious plant that has been cultivated worldwide for thousands of years, is known for its secondary metabolites, especially cannabinoids, which possess several medicinal effects. In this study, we investigated the autopolyploidization effects on the biosynthes...
2023-09-21 | MTBLS6032 | MetaboLights
TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
MetabolomicsClinical efficacy of Yiqi Yangxue formula on knee osteoarthritis and unraveling therapeutic mechanism through plasma metabolites in rats.

OBJECTIVE: To observe the clinical efficacy and safety of Yiqi Yangxue formula (YQYXF) on knee osteoarthritis (KOA), and to explore the underlying therapeutic mechanism of YQYXF through endogenous differential metabolites and their related metabolic pathways.

METHOD...

2024-03-25 | MTBLS5667 | MetaboLights
ProteomicsInteractome analysis of RESC6 and RESC8 from Trypanosoma brucei
Trypanosoma brucei requires extensive uridine insertion and deletion RNA editing of most of their mitochondrial transcripts to generate translatable open reading frames. The RNA editing substrate binding complex (RESC) serves as the scaffold that coordinates the protein-protein and protein-RNA inter...
ORGANISM(S): Trypanosoma brucei 
2023-10-12 | PXD046097 | Pride
Trypanosoma brucei Turboid Interactome 
ProteomicsHigh-quality and robust protein quantification in large clinical cohort of serum samples with IonStar
Robust, reliable quantification of large sample cohorts is often essential for meaningful clinical or pharmaceutical proteomics investigations, but it is technically challenging. When analyzing very large numbers of samples, isotope labeling approaches may suffer from substantial batch effects; and...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD036822 | Pride
Large-cohort clinical study  quantitative proteomics  ionstar  liquid chromatography-mass spectrometry  high-resolution mass spectrometry 
ProteomicsA brain signaling framework for stress-induced depression and ketamine treatment elucidated by phosphoproteomics
Depression is a common affective disorder characterized by significant and persistent low mood.Ketamine, an N-methyl-D-aspartate receptor (NMDAR) antagonist, is reported to have a rapid and durable antidepressant effect.
ORGANISM(S): Mus Musculus 
2019-11-18 | PXD016302 |
ProteomicsTumor necrosis factor α-induced protein 1 as a novel tumor suppressor through selective downregulation of CSNK2B blocks Nuclear Factor-κB activation in hepatocellular carcinoma
Background: Tumor necrosis factor α-induced protein 1 (TNFAIP1) is frequently downregulated in cancer cell lines and promotes cancer cell apoptosis. However, its role, clinical significance and molecular mechanisms in hepatocellular carcinoma (HCC) are unknown. Methods: The expression of TNFAIP1 in...
ORGANISM(S): Homo Sapiens 
2019-11-19 | PXD016329 |
ProteomicsTranscriptomic and proteomic analysis of human brain tissue from epileptic and non-epileptic groups
Abstract Objective: Epilepsy is a prevalent neurological disorder marked by seizures due to abnormal brain neuron discharge. Its pathological mechanism remains incompletely understood. This study utilizes transcriptomic and proteomic analyses on epileptic lesions from patients and brain tissue from ...
ORGANISM(S): Homo Sapiens 
2024-08-01 | PXD054520 |
ProteomicsH3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants
Monomethylation of histone H3 lysine 4 (H3K4me1) marks enhancers in mammals. However, the function of H3K4me1 in plants remains largely unclear. Here, we analyzed the genome-wide distribution of H3K4me1 in diverse species across evolution, revealing a distinctive H3K4me1 distribution pattern in land...
ORGANISM(S): Oryza Sativa 
2025-09-23 | PXD068723 |
ProteomicsTo explore the binding protein of HKDC1 by IP-MS
We used Hep3B cells expressing Flag tagged HKDC1 to explore the binding protein of HKDC1 by IP-MS
ORGANISM(S): Homo Sapiens 
2023-11-29 | PXD047388 |
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