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ProteomicsHOPE-fixation of lung tissue allows retrospective proteome and phosphoproteome studies
Hepes-glutamic acid buffer mediated Organic solvent Protection Effect (HOPE)-fixation has been introduced as an alternative to formalin fixation of clinical samples. Beyond preservation of morphological structures for histology, HOPE-fixation was demonstrated to be compatible with recent methods for...
ORGANISM(S): Homo sapiens (Human) 
2014-05-22 | PXD000836 | Pride
Post-translational modifications Hope-fixation technique Phosphorylation Biobank Proteome Lung tissues Lc-ms/ms 
ProteomicsNsp1 and Nsp2 interactome and proteome
The samples represent pulldowns of protein Nsp1 and Nsp2 from SARS-CoV and SARS-CoV2, as well its unfunctional mutants. Additionally, total proteomes of corresponding samples were analyzed.
ORGANISM(S): Homo sapiens (Human) 
2022-05-10 | PXD024480 | Pride
Extracellular vesicle Cerebrospinal fluid Traumatic brain injury 
ProteomicsTargeted assay for differentiation and monitoring the concentration of GDF 8 (Myostatin) and GDF11 in mouse serum
Abstract Growth differentiation factor 11 (GDF11) and Myostatin (GDF8) are circulating factor shown to reduce cardiac hypertrophy of aged animals. Although GDF11 and GDF8 have high structural homology, it seems that GDF11 is had a more potent effect on reducing cardiomyocytes size, albeit GDF11 qua...
ORGANISM(S): Mus Musculus 
2021-01-24 | PXD015838 | panorama
ProteomicsG-CSF/NAMPT signaling drives neutrophil dysfunction and enhances bacterial infection susceptibility in cancer patients
Despite advancements in cancer therapies, bacterial complications remain a major challenge, delaying treatment and worsening outcomes. While immunosuppressive therapies and prolonged hospitalizations contribute, they do not fully explain the elevated infection risk in cancer patients. Here we show t...
ORGANISM(S): Mus musculus (Mouse) 
2025-10-17 | PXD069569 | Pride
Granulopoiesis Gram-negative pathogens Head and neck cancer Antibacterial responses G-csf/nampt signaling Neutrophils Pseudomonas aeruginosa Cancer 
ProteomicsTargeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation
Protein glycosylation is an essential posttranslational modification in all domains of life. Its impairment in human can result in severe diseases named Congenital Disorders of Glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible for proper glycosylation are polytopic membrane p...
ORGANISM(S): Homo Sapiens 
2024-01-30 | PXD048072 | panorama
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